{"id":"W4403727040","doi":"10.14309/01.ajg.0001032124.58501.0c","title":"S689 Efficacy and Pharmacokinetic Results From Ongoing Dose Escalation in RESOLVE, a Phase 1b/2a Study of EP-104GI (Extended-Release Fluticasone Propionate Intra-Esophageal Injection) for Eosinophilic Esophagitis","year":2024,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Eosinophilic Esophagitis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Aurinia (Canada)","funders":"","keywords":"Medicine; Eosinophilic esophagitis; Fluticasone propionate; Pharmacokinetics; Fluticasone; Gastroenterology; Esophagitis; Internal medicine; Pharmacology; Corticosteroid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001645317,0.0012135,0.001763596,0.0005708946,0.0004251688,0.001226745,0.000814832,0.001927678,0.007084628],"category_scores_gemma":[0.001558779,0.0005982225,0.001657088,0.000481813,0.0006113936,0.001029548,0.0003039423,0.003428177,0.001919941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000741354,"about_ca_system_score_gemma":0.001285316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006228434,"about_ca_topic_score_gemma":0.001643136,"domain_scores_codex":[0.9993087,0.0002859237,0.0000518383,0.0001062338,0.0001467494,0.000100546],"domain_scores_gemma":[0.9990382,0.0001891005,0.0003072072,0.00005678401,0.0001317326,0.00027695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5486311,0.08174351,0.007176409,0.002976897,0.003096512,0.0007572453,0.0005004843,0.004659929,0.09297322,0.0008347597,0.02456062,0.2320894],"study_design_scores_gemma":[0.5277687,0.4294419,0.01564857,0.0001374002,0.001221605,0.0009561322,0.0001208047,0.002123819,0.008246601,0.0004055062,0.01384911,0.00007987991],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760528,0.007443,0.00119614,0.0009983281,0.0002432677,0.002680658,0.005016975,0.0003727154,0.005996147],"genre_scores_gemma":[0.9704699,0.004440864,0.002914576,0.002618411,0.0003957887,0.002416289,0.009905303,0.0001408443,0.006698036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007084628,"threshold_uncertainty_score":0.02370048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586625958593655,"score_gpt":0.3180205671883538,"score_spread":0.3021543076024172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}