{"id":"W4403734567","doi":"10.1038/s41594-024-01405-4","title":"DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency","year":2024,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Epigenome; Biology; DNA methylation; Epigenetics; Histone; Cell biology; Reprogramming; PRC2; Embryonic stem cell; Genetics; Gene; Histone H3; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840209,0.0002707959,0.0001672707,0.00008544591,0.0002547891,0.00009568017,0.000433513,0.0005960884,0.00007886369],"category_scores_gemma":[0.0001351773,0.0001489964,0.0002033451,0.000283842,0.0001525709,0.000006595081,0.0001889976,0.0005819682,0.00001070189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001444491,"about_ca_system_score_gemma":0.00004647865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005236453,"about_ca_topic_score_gemma":0.00003967988,"domain_scores_codex":[0.9984424,0.0002587372,0.0002534243,0.0005677677,0.0001600782,0.0003176317],"domain_scores_gemma":[0.9992989,0.00006146399,0.0000843327,0.0004174914,0.00008396711,0.00005382049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004064877,0.00000257123,0.0006313871,0.000009114445,0.000160322,0.000008263396,0.00008061656,0.00009108794,0.9920012,0.002411691,0.0001395597,0.004423507],"study_design_scores_gemma":[0.0003151058,0.0001356884,0.03488151,0.00001689883,0.00008699736,0.00002141975,0.0000676652,0.0006691396,0.9197053,0.02089194,0.02287245,0.0003359353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9258828,0.06874863,0.001554269,0.002106026,0.0008528788,0.0002697651,0.000094925,0.00003581769,0.0004548991],"genre_scores_gemma":[0.9971807,0.000622562,0.0002765976,0.0004528767,0.0007877044,0.00002134246,0.000477208,0.00003461091,0.0001463934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07229598,"threshold_uncertainty_score":0.6075897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00369415205165175,"score_gpt":0.2724218464716451,"score_spread":0.2687276944199934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}