{"id":"W4403734567","doi":"10.1038/s41594-024-01405-4","title":"DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency","year":2024,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Epigenome; Biology; DNA methylation; Epigenetics; Histone; Cell biology; Reprogramming; PRC2; Embryonic stem cell; Genetics; Gene; Histone H3; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878501,0.0001381917,0.0002948458,0.0001469184,0.0003441095,0.001079796,0.0003022841,0.0003339235,0.002657592],"category_scores_gemma":[0.0003936277,0.0002524432,0.0001721656,0.0001441531,0.000488273,0.0007476117,0.0006654527,0.001028857,0.0009966585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005284356,"about_ca_system_score_gemma":0.0002682211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008333423,"about_ca_topic_score_gemma":0.002688116,"domain_scores_codex":[0.9998038,0.00001590554,0.000009627454,0.00004930636,0.00005670324,0.00006458862],"domain_scores_gemma":[0.9998036,0.000024474,0.00003104107,0.0000296092,0.00003873006,0.00007266091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001893085,0.000009228444,0.001666997,0.00002113375,0.000005654463,0.00008750461,0.00008891491,0.0001620539,0.9908087,0.00222184,0.00018756,0.004551083],"study_design_scores_gemma":[0.00005492272,0.0003007369,0.08344238,0.0000254732,0.00001694599,0.0003624042,0.0005843542,0.005201529,0.8967519,0.004141239,0.009076928,0.0000411619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883955,0.0009004734,0.005357052,0.0003051937,0.00005449839,0.000009365968,0.0002146896,0.0001695572,0.004593729],"genre_scores_gemma":[0.9954704,0.0002043012,0.0006471619,0.00008999802,0.00001314602,0.000004939667,0.0001729745,0.0000455949,0.003351454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002657592,"threshold_uncertainty_score":0.00889051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00369415205165175,"score_gpt":0.2724218464716451,"score_spread":0.2687276944199934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}