{"id":"W4403748505","doi":"10.1016/j.toxicon.2024.108154","title":"Investigation of 44-methylgambierone reactivity with periodate: Structural reassignment, solvent instability and formation of a furanoid analogue","year":2024,"lang":"en","type":"article","venue":"Toxicon","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada","funders":"Norges Forskningsråd; Ministry of Business, Innovation and Employment","keywords":"Periodate; Reactivity (psychology); Chemistry; Solvent; Instability; Organic chemistry; Medicinal chemistry; Medicine; Physics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001779175,0.00007709875,0.0001143616,0.00003905682,0.00002206665,0.00001224331,0.00003475554,0.00006189124,0.00000510847],"category_scores_gemma":[0.00002642446,0.00006098402,0.00002931932,0.0001010096,0.0001088045,0.00002532258,0.00002669106,0.00003876438,1.836229e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001575575,"about_ca_system_score_gemma":0.00003889355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002951781,"about_ca_topic_score_gemma":0.00004750715,"domain_scores_codex":[0.9994421,0.0000478371,0.0001842661,0.0001715364,0.00008828122,0.00006600343],"domain_scores_gemma":[0.9996569,0.000007905575,0.00009251269,0.0001639871,0.0000499781,0.00002869971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005924548,0.000006783973,0.002917424,0.0001706442,0.00002150457,1.629632e-7,0.0002402595,0.00001715784,0.9935278,0.00007596229,0.00001778787,0.002945279],"study_design_scores_gemma":[0.0001837764,0.000293527,0.01838811,0.00004084572,0.00003037097,0.00000532354,0.0001101666,0.000763097,0.9798939,0.000110257,0.0001134135,0.0000671954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961789,0.0005766101,0.002946815,0.00003629379,0.00002609648,0.0001380657,0.00003523132,0.000006202134,0.00005581118],"genre_scores_gemma":[0.9991573,0.00007327969,0.0003042694,0.000009174061,0.0000172646,0.000007545527,0.0004073399,0.000006487294,0.00001731081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01547069,"threshold_uncertainty_score":0.2486856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013152754803526,"score_gpt":0.2399543787668806,"score_spread":0.2268016239633545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}