{"id":"W4403750561","doi":"10.1038/s41409-024-02449-2","title":"Measurable residual mutated IDH2 before allogeneic transplant for acute myeloid leukemia","year":2024,"lang":"en","type":"article","venue":"Bone Marrow Transplantation","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; U.S. Navy; Genentech; Health Resources and Services Administration; Syndax Pharmaceuticals; Office of Naval Research; Jazz Pharmaceuticals; AstraZeneca; National Institutes of Health; U.S. Department of Health and Human Services; Foundation for the National Institutes of Health; Takeda Pharmaceuticals U.S.A.; Amgen; Gilead Sciences; U.S. Department of Defense","keywords":"Medicine; Myeloid leukemia; IDH2; Minimal residual disease; Leukemia; Transplantation; Myeloid; Residual; Cancer research; Immunology; Mutation; Internal medicine; IDH1; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003981214,0.00009446459,0.0002532047,0.000211055,0.0003078426,0.0005377585,0.0001651772,0.0001678199,0.00135998],"category_scores_gemma":[0.0009533369,0.00007708008,0.0001618384,0.0002634723,0.000176653,0.0002763425,0.0001820851,0.000548208,0.0002347653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000517375,"about_ca_system_score_gemma":0.0005305106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267106,"about_ca_topic_score_gemma":0.003410252,"domain_scores_codex":[0.9997941,0.00003592245,0.00001905347,0.00004009022,0.00005565073,0.00005520691],"domain_scores_gemma":[0.9996297,0.0000831209,0.0001014394,0.00003294172,0.00003169279,0.0001211191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003752818,0.0004174004,0.9286202,0.00008272308,0.00007287627,0.002004969,0.0002180143,0.0004337411,0.01037235,0.0002990969,0.001814883,0.05191093],"study_design_scores_gemma":[0.000118968,0.003260541,0.9778001,0.00005773594,0.00008858303,0.005473958,0.0002625572,0.001056983,0.00554842,0.000447952,0.005869019,0.00001519642],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958107,0.001382284,0.0003472682,0.0001673765,0.00003961284,0.00003254575,0.0002771702,0.00001919254,0.001923849],"genre_scores_gemma":[0.9992018,0.0001851756,0.00007972714,0.0000801462,0.00001399121,0.000005025238,0.0002240943,0.000001839793,0.000208185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135998,"threshold_uncertainty_score":0.004549563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978419736761727,"score_gpt":0.2969909554947179,"score_spread":0.2772067581271006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}