{"id":"W4403750561","doi":"10.1038/s41409-024-02449-2","title":"Measurable residual mutated IDH2 before allogeneic transplant for acute myeloid leukemia","year":2024,"lang":"en","type":"article","venue":"Bone Marrow Transplantation","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; U.S. Navy; Genentech; Health Resources and Services Administration; Syndax Pharmaceuticals; Office of Naval Research; Jazz Pharmaceuticals; AstraZeneca; National Institutes of Health; U.S. Department of Health and Human Services; Foundation for the National Institutes of Health; Takeda Pharmaceuticals U.S.A.; Amgen; Gilead Sciences; U.S. Department of Defense","keywords":"Medicine; Myeloid leukemia; IDH2; Minimal residual disease; Leukemia; Transplantation; Myeloid; Residual; Cancer research; Immunology; Mutation; Internal medicine; IDH1; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007076035,0.000407963,0.0005480727,0.0004808792,0.0002128713,0.0001164447,0.0001823525,0.0003337133,0.0001640234],"category_scores_gemma":[0.00002675839,0.0003573973,0.0002902978,0.0005778276,0.0001236132,0.0003239263,0.000009446193,0.0005285637,0.0001550082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007790736,"about_ca_system_score_gemma":0.001207763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001946378,"about_ca_topic_score_gemma":0.0002753672,"domain_scores_codex":[0.9969816,0.00009535621,0.0006290315,0.000764352,0.0007402253,0.0007895031],"domain_scores_gemma":[0.9988773,0.0002053325,0.00005827809,0.0003517232,0.0002043343,0.0003030368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009387953,0.0001211918,0.001301122,0.005042288,0.001935427,0.006048227,0.005257258,0.0002355081,0.9308934,0.001521631,0.01021808,0.0280379],"study_design_scores_gemma":[0.02860328,0.004834219,0.03418547,0.004625842,0.01327576,0.01909976,0.0005996912,0.0345542,0.8283288,0.003507931,0.02589703,0.002488062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705352,0.001537024,0.01660526,0.003844013,0.000495191,0.002550955,0.001645984,0.0008070004,0.001979408],"genre_scores_gemma":[0.9826494,0.001704989,0.003880008,0.000348046,0.0004103738,0.0004332223,0.00505964,0.0001586238,0.005355738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1025646,"threshold_uncertainty_score":0.9998878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978419736761727,"score_gpt":0.2969909554947179,"score_spread":0.2772067581271006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}