{"id":"W4403750647","doi":"10.1038/s41591-024-03327-6","title":"Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial","year":2024,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Toronto General Hospital; Women and Children’s Health Research Institute; University of Alberta","funders":"","keywords":"Semaglutide; Medicine; Overweight; Diabetes mellitus; Kidney disease; Obesity; Randomized controlled trial; Placebo; Type 2 diabetes; Disease; Clinical trial; Internal medicine; Physical therapy; Alternative medicine; Endocrinology; Liraglutide; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001933478,0.0004602144,0.002260675,0.0004331233,0.00005589054,0.00004267048,0.0001111466,0.0002947212,0.000342527],"category_scores_gemma":[0.001733232,0.0002187437,0.0002325246,0.0004605483,0.0004019176,0.0001169359,0.00007318967,0.0009381672,0.0000149261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218818,"about_ca_system_score_gemma":0.0004952272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001057999,"about_ca_topic_score_gemma":0.00003438213,"domain_scores_codex":[0.9968315,0.0002618738,0.0008850527,0.0007585163,0.0007816721,0.0004813905],"domain_scores_gemma":[0.9974288,0.001148632,0.0001657147,0.0004363034,0.00009911687,0.0007214568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9243422,0.0009859465,0.06577627,0.0006136643,0.001579914,0.000195285,0.0000865857,4.672224e-7,0.000001857767,0.0002541794,0.004392839,0.001770816],"study_design_scores_gemma":[0.9695044,0.004091132,0.01053431,0.002976523,0.00497825,6.738051e-7,0.00001049928,0.0008625861,0.00000772012,0.00007536161,0.006720523,0.0002380158],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719894,0.007981636,0.00001358218,0.005492775,0.001292073,0.01188753,0.00001382706,0.000150295,0.001178859],"genre_scores_gemma":[0.9907111,0.0003449146,0.0001087678,0.002085919,0.001370141,0.0007050817,0.0002877421,0.00005443349,0.004331909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05524196,"threshold_uncertainty_score":0.8920109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479512912896411,"score_gpt":0.3201104647047129,"score_spread":0.3053153355757487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}