{"id":"W4403751724","doi":"10.1016/j.anai.2024.08.227","title":"PHARMACOKINETICS AND PHARMACODYNAMICS FOLLOWING REPEAT DOSING OF EPINEPHRINE NASAL SPRAY VERSUS INTRAMUSCULAR INJECTION DURING ALLERGIC RHINITIS","year":2024,"lang":"en","type":"article","venue":"Annals of Allergy Asthma & Immunology","topic":"Allergic Rhinitis and Sensitization","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston Health Sciences Centre","funders":"","keywords":"Medicine; Dosing; Pharmacodynamics; Pharmacokinetics; Epinephrine; Nasal spray; Nasal administration; Anesthesia; Intramuscular injection; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002660898,0.0002786188,0.0005656015,0.0003967401,0.0001005307,0.00002349291,0.00009625554,0.0002073338,0.0001051162],"category_scores_gemma":[0.0001054814,0.0002858486,0.0002623578,0.0003649679,0.0002015245,0.0002179144,0.0001182377,0.0003704294,0.000005061382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003448426,"about_ca_system_score_gemma":0.00008535262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008805079,"about_ca_topic_score_gemma":0.00002017779,"domain_scores_codex":[0.998098,0.0001216187,0.0007104425,0.0004181642,0.000280544,0.0003712813],"domain_scores_gemma":[0.9990986,0.0001247905,0.0001925196,0.0002562719,0.0002387621,0.00008903901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005565293,0.0003793329,0.00009129527,0.0007286145,0.008831671,0.001728976,0.002683176,0.00226067,0.9199874,0.005541604,0.0004265903,0.05177534],"study_design_scores_gemma":[0.03150309,0.009134213,0.08434462,0.004208497,0.0003278505,0.005586518,0.002362256,0.05583237,0.6953021,0.0008451124,0.1083979,0.002155457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781665,0.01713781,0.0005281013,0.001115003,0.001350477,0.0002010175,0.000008170764,0.0001097657,0.001383121],"genre_scores_gemma":[0.9767962,0.02205191,0.0005219631,0.000108932,0.0001993932,0.000006358809,0.0001056207,0.00005751991,0.0001521378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2246853,"threshold_uncertainty_score":0.9999593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02293658658634925,"score_gpt":0.3074884636583906,"score_spread":0.2845518770720413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}