{"id":"W4403758756","doi":"10.1101/2024.10.23.619899","title":"Unc-51-like Kinase 1 (ULK1) Regulates Bacterial Ubiquitylation and p62 Recruitment during Xenophagic Clearance of <i>Listeria monocyt</i> ogenes","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Listeria monocytogenes; ULK1; Cell biology; Listeria; Kinase; Chemistry; Ubiquitin; Microbiology; Protein kinase A; Biology; Bacteria; Biochemistry; Genetics; AMPK","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001064251,0.000174353,0.0001757027,0.0001055846,0.0002176488,0.0003155897,0.0001202482,0.0002468918,0.0009098749],"category_scores_gemma":[0.00009400801,0.0001058624,0.0001540126,0.00009665135,0.0001690184,0.000150839,0.0001717699,0.0003127196,0.000442458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004036145,"about_ca_system_score_gemma":0.0001846731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007061455,"about_ca_topic_score_gemma":0.0009089586,"domain_scores_codex":[0.9998844,0.00001678177,0.00001022247,0.00002561817,0.00001834445,0.00004464361],"domain_scores_gemma":[0.9999259,0.00001057214,0.00002648963,0.000007597575,0.000007589681,0.00002191068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002670363,0.00001883793,0.0004563775,0.00003129762,0.000002199268,0.00005996996,0.00001541137,0.00004211261,0.998515,0.00007796579,0.00005748651,0.0004565275],"study_design_scores_gemma":[0.00002335155,0.0001521373,0.02958871,0.00001237095,0.000009221077,0.0002536924,0.0001006365,0.001443958,0.9664627,0.00009086142,0.001855559,0.000006854431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996577,0.00128592,0.0008483607,0.00008404056,0.0000190204,0.000007087964,0.0003396729,0.00003537097,0.0008035983],"genre_scores_gemma":[0.9974164,0.0003608793,0.0005217611,0.00005342283,0.000004775431,0.00001103888,0.0003715162,0.00001115756,0.001249083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009098749,"threshold_uncertainty_score":0.00304383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02592275841397224,"score_gpt":0.2599569293788658,"score_spread":0.2340341709648935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}