{"id":"W4403778988","doi":"10.1016/j.jvssci.2024.100262","title":"Chronic Knockout of the ETS Transcription Factor ERG Promotes Loss of Endothelial Cell Identity and Endothelial Cell Dysfunction in an Aortic Endothelial Cell Model Relevant For Atherosclerosis","year":2024,"lang":"en","type":"article","venue":"JVS Vascular Science","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network","funders":"","keywords":"Endothelial stem cell; Transcription factor; Endothelial dysfunction; Cell; Medicine; Cancer research; Cell biology; Biology; Internal medicine; Genetics; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008844727,0.0002556613,0.0003190644,0.0002376781,0.0002942247,0.0002138531,0.0007076715,0.0001120474,0.00003536008],"category_scores_gemma":[0.0001181147,0.000194115,0.0002931989,0.0006906071,0.0006617521,0.001136043,0.0001178651,0.0002578112,0.000007097036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000169912,"about_ca_system_score_gemma":0.0003739874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001238031,"about_ca_topic_score_gemma":0.00007235065,"domain_scores_codex":[0.9970152,0.0001643323,0.0005295796,0.0008741954,0.0009134593,0.0005031914],"domain_scores_gemma":[0.9990335,0.0001050241,0.0001905909,0.0004659453,0.00008801284,0.0001169243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003406794,0.0001684301,0.0002630361,0.0003691263,0.000002406595,6.825549e-7,0.00204148,0.001521839,0.9940517,0.0003370224,0.000001524395,0.001208686],"study_design_scores_gemma":[0.0009104313,0.0003130714,0.0005119065,0.0001115905,0.00003763756,0.000001873746,0.00006453455,0.1460896,0.8510005,0.000685534,0.00008972357,0.000183579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989925,0.0002800087,0.007631231,0.00003890369,0.0008242519,0.0009333392,0.000253302,0.00004891511,0.00006510401],"genre_scores_gemma":[0.9989479,0.0002383535,0.0004280363,0.00002500555,0.000111053,0.00003392335,0.000001008839,0.00004377849,0.0001709116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1445678,"threshold_uncertainty_score":0.7915781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03149266995795677,"score_gpt":0.260362997521088,"score_spread":0.2288703275631312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}