{"id":"W4403783102","doi":"10.1021/acs.molpharmaceut.4c00952","title":"Synthesis and Evaluation of <sup>68</sup>Ga- and <sup>177</sup>Lu-Labeled [Pro<sup>14</sup>]bombesin(8–14) Derivatives for Detection and Radioligand Therapy of Gastrin-Releasing Peptide Receptor-Expressing Cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; China Scholarship Council","keywords":"Bombesin; Radioligand; Peptide receptor; Gastrin; Chemistry; Peptide; Receptor; Radiochemistry; Neuropeptide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005440824,0.0004376218,0.0005643418,0.0002399493,0.0002772095,0.0001552066,0.0001849828,0.0001441574,0.00003065191],"category_scores_gemma":[0.000561788,0.0004107588,0.0001271643,0.0004198683,0.0005021052,0.0003540735,0.0001327609,0.0003305117,0.000001325328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007263495,"about_ca_system_score_gemma":0.0001215571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002745113,"about_ca_topic_score_gemma":0.000001071084,"domain_scores_codex":[0.9969013,0.0006192274,0.000576466,0.0009091579,0.0005000351,0.0004938067],"domain_scores_gemma":[0.9983687,0.0007102532,0.0002487851,0.0002518473,0.0002518116,0.0001685405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000462747,0.00007854531,0.0001251694,0.0004348608,0.0000943989,0.000007874801,0.001124366,0.008723672,0.8890142,0.00005565805,0.00003605039,0.0998424],"study_design_scores_gemma":[0.001256189,0.0002878349,0.0001806866,0.0003360331,0.0002187604,0.00003409205,0.0002217909,0.2650431,0.7302096,0.000214377,0.00172436,0.00027324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898778,0.007931206,0.0007110127,0.0001272419,0.00007009249,0.001055624,0.00009759211,0.00006938034,0.00006002268],"genre_scores_gemma":[0.9906498,0.007940746,0.0007815911,0.0002669931,0.0001107493,0.0001204808,0.000004538896,0.0001005032,0.00002459544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2563194,"threshold_uncertainty_score":0.9998344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07831720764271137,"score_gpt":0.3535035688313297,"score_spread":0.2751863611886183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}