{"id":"W4403783102","doi":"10.1021/acs.molpharmaceut.4c00952","title":"Synthesis and Evaluation of <sup>68</sup>Ga- and <sup>177</sup>Lu-Labeled [Pro<sup>14</sup>]bombesin(8–14) Derivatives for Detection and Radioligand Therapy of Gastrin-Releasing Peptide Receptor-Expressing Cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; China Scholarship Council","keywords":"Bombesin; Radioligand; Peptide receptor; Gastrin; Chemistry; Peptide; Receptor; Radiochemistry; Neuropeptide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002019553,0.0004336271,0.0003484046,0.0001465416,0.0001640729,0.0002045986,0.0003809092,0.0004408947,0.0006536031],"category_scores_gemma":[0.0001861658,0.0002203947,0.0002484678,0.0002211879,0.0001686093,0.0002600731,0.0001752003,0.0003489156,0.000412014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003852019,"about_ca_system_score_gemma":0.0003292798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009981185,"about_ca_topic_score_gemma":0.001605172,"domain_scores_codex":[0.9998933,0.0000211777,0.00001137303,0.00001855248,0.00003678815,0.00001883594],"domain_scores_gemma":[0.9999216,0.00001013983,0.0000214954,0.000008443449,0.00001721198,0.00002125476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007684201,0.00001958872,0.00004294985,0.00006603589,0.000005825905,0.0000614946,0.00001687404,0.0001862773,0.9975671,0.00008476024,0.00002667371,0.001845755],"study_design_scores_gemma":[0.00003437603,0.0007053278,0.0006913779,0.000006285723,0.00002528161,0.0002448629,0.00001530997,0.0008445252,0.994458,0.00001633593,0.002946135,0.00001221551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824153,0.003926618,0.0108182,0.00009873707,0.00002558607,0.0002798202,0.0003736329,0.00009184366,0.001970471],"genre_scores_gemma":[0.9567897,0.003537653,0.03446049,0.0001452593,0.0000181187,0.0002497753,0.001097568,0.00005244804,0.003648894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009981185,"threshold_uncertainty_score":0.002794802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07831720764271137,"score_gpt":0.3535035688313297,"score_spread":0.2751863611886183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}