{"id":"W4403783204","doi":"10.1002/acn3.52229","title":"Subcutaneous ocrelizumab in multiple sclerosis: Results of the Phase 1b <scp>OCARINA</scp> I study","year":2024,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"F. Hoffmann-La Roche","keywords":"Ocrelizumab; Medicine; Multiple sclerosis; Dermatology; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005279047,0.0009206017,0.001169203,0.0002262574,0.0003191634,0.0006964762,0.0004201697,0.001026282,0.001877821],"category_scores_gemma":[0.001736447,0.0002129515,0.00118043,0.0002980786,0.0003355711,0.000443149,0.0002640313,0.001410302,0.0005536334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004039536,"about_ca_system_score_gemma":0.001240901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009939427,"about_ca_topic_score_gemma":0.001254746,"domain_scores_codex":[0.9990791,0.000536216,0.00006597452,0.00008427823,0.0001451141,0.00008938637],"domain_scores_gemma":[0.9982711,0.0003434563,0.0003998539,0.0001387356,0.0002299219,0.000616914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6009977,0.04666349,0.03322811,0.001910768,0.00565616,0.000491519,0.000378027,0.00182146,0.04237142,0.0002967117,0.01407557,0.252109],"study_design_scores_gemma":[0.5766883,0.3158806,0.08678617,0.0002208621,0.002723886,0.0006909242,0.00006972552,0.001146421,0.005162108,0.0001807404,0.01041161,0.00003872913],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733375,0.01528339,0.0008587505,0.001595771,0.0001999976,0.002026681,0.002546332,0.0001100701,0.004041479],"genre_scores_gemma":[0.9817802,0.0060749,0.001782686,0.002256117,0.0004197676,0.001248823,0.004360306,0.00004178686,0.002035364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005279047,"threshold_uncertainty_score":0.02791864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3016268555723889,"score_gpt":0.4485424615953322,"score_spread":0.1469156060229432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}