{"id":"W4403789330","doi":"10.1093/brain/awae349","title":"Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts","year":2024,"lang":"en","type":"review","venue":"Brain","topic":"Autoimmune Neurological Disorders and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wellcome Trust; Agence Nationale de la Recherche; NIHR Oxford Biomedical Research Centre; BMA Foundation for Medical Research; Fundação de Amparo à Pesquisa do Estado de São Paulo; Medical Research Council Canada; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Biomedical Research Council; Medical Research Council; Wellcome","keywords":"Genome-wide association study; Biology; Computational biology; Genetics; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003106178,0.0008726461,0.001185343,0.0006877918,0.0009129842,0.001521771,0.00105341,0.001057766,0.001862384],"category_scores_gemma":[0.003645892,0.0004918663,0.002701729,0.001675121,0.0004330051,0.0004070932,0.001018094,0.001254194,0.0003345818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003913094,"about_ca_system_score_gemma":0.0007812633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008843935,"about_ca_topic_score_gemma":0.009112527,"domain_scores_codex":[0.9980894,0.0005235202,0.0001584523,0.0008616137,0.000148407,0.0002186732],"domain_scores_gemma":[0.9982949,0.0006368217,0.0003076448,0.0003657131,0.0001981009,0.0001967568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003840208,0.0001177404,0.9680635,0.0002762823,0.01101534,0.001300297,0.0003280861,0.0009284305,0.004184278,0.0002994438,0.002269882,0.007376562],"study_design_scores_gemma":[0.0007018957,0.0003098618,0.9830186,0.00006042165,0.009151012,0.001257442,0.000217741,0.002228993,0.0005085759,0.0003620179,0.002144604,0.00003877817],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901837,0.003401267,0.001630989,0.0002007591,0.00005169617,0.00004608567,0.00388606,0.00005749486,0.0005420087],"genre_scores_gemma":[0.9942036,0.000669434,0.001035906,0.0001221272,0.00003221543,0.00007490513,0.003512204,0.0000308329,0.000318651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008843935,"threshold_uncertainty_score":0.01758492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03050447014899929,"score_gpt":0.3444628971552436,"score_spread":0.3139584270062443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}