{"id":"W4403794532","doi":"10.1101/2024.10.25.620260","title":"Thymidine kinase-expressing yellow fever 17D reporter virus facilitates prodrug activation and bioorthogonal labelling of infected cells","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"KU Leuven; Fonds Wetenschappelijk Onderzoek; European Commission","keywords":"Bioorthogonal chemistry; Labelling; Prodrug; Thymidine kinase; Virology; Thymidine; Virus; Chemistry; Biology; Biochemistry; Combinatorial chemistry; Click chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119062,0.0002622996,0.0001691085,0.0001243555,0.00008094139,0.0002757556,0.0001455352,0.0002658574,0.001318407],"category_scores_gemma":[0.0001108924,0.0001560392,0.0001662505,0.00009820292,0.0002233022,0.0001548472,0.0002916964,0.0003861096,0.000554732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002765357,"about_ca_system_score_gemma":0.0001845196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003471677,"about_ca_topic_score_gemma":0.0002944749,"domain_scores_codex":[0.9998971,0.00001283178,0.000006403463,0.00002329627,0.00003196512,0.00002831372],"domain_scores_gemma":[0.9999539,0.00001011216,0.00001255848,0.00000938377,0.000006533688,0.000007522015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002470786,0.000005913181,0.00008944092,0.00001598385,0.000001726745,0.00002793574,0.000008960676,0.00008709807,0.9985245,0.000310095,0.00004019004,0.0008634032],"study_design_scores_gemma":[0.000002492937,0.00001947398,0.0001253487,0.000001123696,0.000001228844,0.00004278594,0.00000284466,0.0005083674,0.9981148,0.00002326608,0.001157426,8.540396e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719114,0.0005264996,0.02251225,0.00009064687,0.00003869684,0.0000431991,0.0002982566,0.0001556795,0.004423444],"genre_scores_gemma":[0.9752266,0.0005747936,0.01667373,0.00003841323,0.000007018021,0.00004937991,0.0005691455,0.00006555514,0.00679539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001318407,"threshold_uncertainty_score":0.004410446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442545027917883,"score_gpt":0.2169979376597222,"score_spread":0.2025724873805433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}