{"id":"W4403806842","doi":"10.1101/2024.10.25.620284","title":"Epigenetic responses in <i>Borrelia</i> -infected Ixodes <i>scapularis</i> ticks: Over-expression of euchromatic histone lysine methyltransferase 2 and no change in DNA methylation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Insect symbiosis and bacterial influences","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Allison University","funders":"","keywords":"Ixodes scapularis; Biology; Euchromatin; Borrelia; Methyltransferase; Epigenetics; DNA methylation; Methylation; Genetics; DNA; Heterochromatin; Gene expression; Gene; Borrelia burgdorferi; Chromatin; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001029152,0.0001937733,0.0001907133,0.0001921916,0.0001345625,0.0002712146,0.00008427549,0.000187592,0.0008835378],"category_scores_gemma":[0.0001122416,0.0001156651,0.0002016342,0.0001082861,0.0001992181,0.00009752178,0.0001233599,0.0003266216,0.0001728319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001804936,"about_ca_system_score_gemma":0.00009985696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000685489,"about_ca_topic_score_gemma":0.0008951597,"domain_scores_codex":[0.9998564,0.00001616278,0.00001142206,0.00005139559,0.00003114388,0.00003349935],"domain_scores_gemma":[0.9998676,0.0000140351,0.00006724184,0.000008930505,0.00001729412,0.00002490645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001587789,0.00001332516,0.00154737,0.00002471141,0.000007525724,0.00002391292,0.00002524773,0.0000159394,0.9976515,0.00001085634,0.00002597907,0.0004948187],"study_design_scores_gemma":[0.00002389425,0.000767609,0.226936,0.00001940841,0.00006447899,0.0006946737,0.0003127411,0.0007616642,0.7683368,0.00007054931,0.00199688,0.0000152174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983192,0.0004748518,0.0004068227,0.0000370007,0.00001299867,0.000007002558,0.0004032683,0.00001998202,0.0003187959],"genre_scores_gemma":[0.997477,0.0002915423,0.0005112368,0.00005474006,0.000008121498,0.00001744331,0.0007096771,0.000007843166,0.0009224027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008835378,"threshold_uncertainty_score":0.002955794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713817935998721,"score_gpt":0.2406716157058108,"score_spread":0.2235334363458236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}