{"id":"W4403811301","doi":"10.1681/asn.202460fy8mwm","title":"Deficiency of Hedgehog Interacting Protein (Hhip) in Endothelial Cells Prevents Kidney Ischemia-Reperfusion-Mediated Renal Tubular Cell Senescence","year":2024,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Senescence; Hedgehog signaling pathway; Kidney; Cell biology; Cancer research; Hedgehog; Ischemia; Cell; Medicine; Biology; Chemistry; Internal medicine; Pathology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006842187,0.0001792092,0.0004450116,0.00006176923,0.00004845052,0.000007839887,0.0004819652,0.0001065355,0.000009658244],"category_scores_gemma":[0.0002685949,0.0001324812,0.0004605274,0.0003296421,0.0004786931,0.000009650003,0.0002726208,0.0003977332,0.000001517123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004169426,"about_ca_system_score_gemma":0.0004171603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005767354,"about_ca_topic_score_gemma":0.000002897845,"domain_scores_codex":[0.9982989,0.0002259305,0.0006910376,0.0002410756,0.0002674465,0.0002756501],"domain_scores_gemma":[0.9985128,0.0001245534,0.0008739076,0.0002520108,0.0001621646,0.00007458126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001604866,0.0001321372,0.0007952144,0.0001313028,0.0001068534,0.00001063441,0.00082772,0.0001331358,0.9932362,0.000001148351,0.004067312,0.0003978613],"study_design_scores_gemma":[0.0004285825,0.0006571991,0.0003075851,0.0002772028,0.00004322976,0.00005847854,0.0006828867,0.0002741094,0.9920543,0.00001885832,0.005082361,0.00011515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973528,0.0009900561,0.0005299987,0.0007013177,0.0001917157,0.0001596978,0.00002667375,0.000004232834,0.00004350909],"genre_scores_gemma":[0.9962463,0.0004040348,0.002366072,0.0006574375,0.000204042,0.000004034442,0.000002228036,0.00002177878,0.00009407783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001836073,"threshold_uncertainty_score":0.5402427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008241808825120612,"score_gpt":0.2493850002461447,"score_spread":0.2411431914210241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}