{"id":"W4403811605","doi":"10.1681/asn.20248eb5tf94","title":"mTOR Inhibition: A Novel Regulator of Soluble CD89 Activity via the Mesangial Transferrin Receptor and Its Therapeutic Potential in IgA Nephropathy","year":2024,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Regulator; Transferrin receptor; Negative regulator; PI3K/AKT/mTOR pathway; Cancer research; Transferrin; Nephropathy; Chemistry; Glomerulonephritis; Receptor; Medicine; Internal medicine; Endocrinology; Kidney; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001270635,0.0003088385,0.0003863657,0.0003035378,0.0001498098,0.0003708951,0.0002995686,0.0003177553,0.001280895],"category_scores_gemma":[0.00005903692,0.00009167854,0.0002932375,0.0001734131,0.0001880363,0.000204518,0.0001914251,0.0006433324,0.0003023034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003506421,"about_ca_system_score_gemma":0.0002008888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003981542,"about_ca_topic_score_gemma":0.001133154,"domain_scores_codex":[0.999949,0.000007066851,0.000004085894,0.000007577721,0.00001290528,0.00001940161],"domain_scores_gemma":[0.9999781,0.000001684005,0.000006724918,0.000001776088,0.000003615639,0.000008268469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005442209,0.001116978,0.001031103,0.0009422965,0.000144246,0.0005190464,0.00007564619,0.0008382151,0.8926069,0.00147276,0.00221233,0.09359824],"study_design_scores_gemma":[0.00403006,0.01741806,0.02125131,0.0001991736,0.0006868365,0.003473681,0.0001710582,0.005577082,0.8721575,0.0007126502,0.07424932,0.00007321643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9574622,0.0329394,0.00228633,0.0008237938,0.0002340619,0.0001784617,0.0004949933,0.0002638897,0.005316845],"genre_scores_gemma":[0.9844974,0.01094634,0.001501269,0.0002046691,0.00006825835,0.00008542667,0.000451215,0.00001540957,0.002229821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001280895,"threshold_uncertainty_score":0.004285038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01394850169079044,"score_gpt":0.2657730001770148,"score_spread":0.2518244984862243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}