{"id":"W4403820808","doi":"10.1101/2024.10.23.619718","title":"<i>SLC4A1</i> MUTATIONS THAT CAUSE DISTAL RENAL TUBULAR ACIDOSIS ALTER CYTOPLASMIC PH AND CELLULAR AUTOPHAGY","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; University of Alberta; Deutsche Forschungsgemeinschaft; Kidney Foundation of Canada; Natural Sciences and Engineering Research Council of Canada; Alberta Health Services","keywords":"Autophagy; Distal renal tubular acidosis; Acidosis; Cytoplasm; Cell biology; Renal tubular acidosis; Chemistry; Mutation; Kidney tubules; Biology; Internal medicine; Endocrinology; Kidney; Pathology; Medicine; Biochemistry; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001459029,0.0004143527,0.000272356,0.0002803277,0.000150344,0.000216156,0.0001617022,0.0003771019,0.001188141],"category_scores_gemma":[0.0001578257,0.0001229722,0.0003448162,0.0001601993,0.0003318628,0.000144407,0.0002131203,0.000293886,0.0003132594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00019588,"about_ca_system_score_gemma":0.0001218123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00057849,"about_ca_topic_score_gemma":0.000611271,"domain_scores_codex":[0.9998177,0.00002933429,0.00003382524,0.00004650346,0.00004008703,0.00003261126],"domain_scores_gemma":[0.9998024,0.00003257542,0.0000848785,0.00001647181,0.00001724401,0.00004646329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009609171,0.00001238023,0.001029884,0.00002551661,0.00001216066,0.0004265257,0.0000145457,0.00004663405,0.9978027,0.00006165154,0.00003427121,0.0004376377],"study_design_scores_gemma":[0.0000324134,0.0002582873,0.04504414,0.0000133921,0.00008000962,0.007347899,0.000102953,0.001401203,0.9430524,0.000173071,0.00247898,0.00001518938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965841,0.0004475538,0.001739128,0.00006410707,0.00001921661,0.0000115809,0.0005232145,0.00007771773,0.0005334708],"genre_scores_gemma":[0.9980085,0.0002150524,0.0008890635,0.00004352651,0.000005899206,0.00001017844,0.0003519309,0.00002390638,0.0004518293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001188141,"threshold_uncertainty_score":0.003974676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007739983395780768,"score_gpt":0.207445470476875,"score_spread":0.1997054870810942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}