{"id":"W4403821879","doi":"10.1101/2024.10.27.620437","title":"Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; Multiple Sclerosis Society; National Institute of Neurological Disorders and Stroke; U.S. Department of Agriculture","keywords":"Remyelination; Neuroinflammation; Multiple sclerosis; Indole test; Neuroscience; Microglia; Medicine; Chemistry; Pharmacology; Inflammation; Psychology; Central nervous system; Internal medicine; Immunology; Biochemistry; Myelin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006413118,0.000402177,0.000429304,0.0004279212,0.00045933,0.0009150883,0.0002988814,0.000699918,0.02775622],"category_scores_gemma":[0.001549034,0.0001387095,0.0003045053,0.0002821863,0.000261529,0.0005064278,0.0005820938,0.0006874239,0.0120683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004506282,"about_ca_system_score_gemma":0.0008393379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006116617,"about_ca_topic_score_gemma":0.001050189,"domain_scores_codex":[0.9997463,0.00003373019,0.00001168886,0.00004061411,0.0001495646,0.00001810682],"domain_scores_gemma":[0.9995227,0.000104005,0.00005883813,0.00004839325,0.000168338,0.00009764328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001303673,0.0001941847,0.001353472,0.001464604,0.00008986851,0.0005219197,0.0001600024,0.0009084673,0.2127676,0.01042363,0.6597673,0.1110452],"study_design_scores_gemma":[0.0002092536,0.0003861691,0.008310552,0.0002815365,0.00009916115,0.0008841269,0.0001589792,0.004879247,0.2150906,0.007824956,0.7618062,0.00006931032],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.2481165,0.03928871,0.107893,0.1670934,0.22075,0.0006208134,0.05629387,0.01784155,0.1421023],"genre_scores_gemma":[0.4297425,0.01748403,0.04559235,0.009149293,0.02157883,0.0003963178,0.02159679,0.005289705,0.4491701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02775622,"threshold_uncertainty_score":0.09285378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815970883678277,"score_gpt":0.2241919128754823,"score_spread":0.2060322040386995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}