{"id":"W4403822422","doi":"10.1093/eurheartj/ehae666.2872","title":"Rationale and design of the SHASTA-3 and SHASTA-4 studies: randomized, double-blind, placebo-controlled, phase 3 studies of plozasiran in patients with severe hypertriglyceridemia","year":2024,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Université de Montréal","funders":"","keywords":"Medicine; Hypertriglyceridemia; Placebo; Randomized controlled trial; Double blind; Internal medicine; Alternative medicine; Pathology; Triglyceride","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08639376,0.007070856,0.009371567,0.002573562,0.003754742,0.004259772,0.004863188,0.008142539,0.01951925],"category_scores_gemma":[0.0555466,0.004976269,0.004631856,0.002696547,0.007457053,0.003800177,0.002171273,0.008991838,0.008822873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002255643,"about_ca_system_score_gemma":0.01089444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008105078,"about_ca_topic_score_gemma":0.002032633,"domain_scores_codex":[0.9592713,0.02591857,0.004058472,0.004200797,0.004218879,0.002332018],"domain_scores_gemma":[0.9795278,0.006910071,0.003289419,0.002901504,0.003892366,0.003478821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8175079,0.01806239,0.006342401,0.03360669,0.004787824,0.0009792086,0.001080662,0.002012436,0.009075463,0.01930019,0.02482632,0.06241851],"study_design_scores_gemma":[0.7895852,0.06597959,0.007606028,0.006568609,0.005760483,0.000451263,0.0003432334,0.003222668,0.003448542,0.01319101,0.1034657,0.0003775866],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01326775,0.00795982,0.01179826,0.003204933,0.003635704,0.9520197,0.003658676,0.0003988044,0.004056335],"genre_scores_gemma":[0.02475607,0.001736165,0.01818801,0.003465886,0.000674569,0.9490445,0.00076338,0.00004846758,0.001323016],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.08639376,"threshold_uncertainty_score":0.4568993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08480128597307014,"score_gpt":0.3394331034615633,"score_spread":0.2546318174884932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}