{"id":"W4403825799","doi":"10.1002/ana.27117","title":"A Novel Mouse Model for Cerebral Inflammatory Demyelination in X‐Linked Adrenoleukodystrophy: Insights into Pathogenesis and Potential Therapeutic Targets","year":2024,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Lucile Packard Foundation for Children's Health; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Stanford Maternal and Child Health Research Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke","keywords":"Adrenoleukodystrophy; Pathology; Medicine; Myelin; Inflammation; Leukodystrophy; Pathogenesis; Immune system; Microglia; Experimental autoimmune encephalomyelitis; Infiltration (HVAC); Myelin oligodendrocyte glycoprotein; Multiple sclerosis; Knockout mouse; Immunology; Central nervous system; Disease; Internal medicine; Peroxisome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005767678,0.001468766,0.0005971891,0.001572551,0.0005105109,0.0007106568,0.0008407067,0.001514078,0.002180902],"category_scores_gemma":[0.0001572318,0.000431269,0.0005691983,0.0004297538,0.0008109725,0.0006688696,0.0004216167,0.001627806,0.0008342412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005118557,"about_ca_system_score_gemma":0.0003852043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004577654,"about_ca_topic_score_gemma":0.001189814,"domain_scores_codex":[0.9996176,0.00006224845,0.0000587851,0.0001077869,0.00009475006,0.000058932],"domain_scores_gemma":[0.999734,0.00003479363,0.00009432273,0.00002929767,0.00002890152,0.0000787208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003002564,0.0003103059,0.0003814938,0.0001358098,0.00002361263,0.0005427741,0.00005292361,0.00008842234,0.9947378,0.0007316064,0.0003065691,0.002388362],"study_design_scores_gemma":[0.0007750536,0.003385192,0.008595973,0.0002773813,0.0003105883,0.01055272,0.0002333275,0.002926085,0.9436452,0.0008344138,0.02840746,0.0000565089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454361,0.01039949,0.03263691,0.002052931,0.0004547541,0.0005038006,0.002718807,0.001115043,0.004682143],"genre_scores_gemma":[0.9056872,0.01100002,0.0564828,0.0007617007,0.0001424662,0.00133881,0.004559343,0.0002084176,0.01981924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002180902,"threshold_uncertainty_score":0.007295847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230036998114409,"score_gpt":0.2742901702320331,"score_spread":0.2512864704205922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}