{"id":"W4403831790","doi":"10.1681/asn.2024fmp001zx","title":"GIT2 Maintains Podocyte Architecture through Suppressing Rac1 Activity and Focal Adhesion Turnover","year":2024,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Podocyte; RAC1; Cell biology; Architecture; Focal adhesion; Biology; Chemistry; Neuroscience; Kidney; Endocrinology; Signal transduction; Proteinuria; History","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023331,0.000373159,0.0002354243,0.0002243505,0.000229615,0.0003729624,0.0002676514,0.000280761,0.001375396],"category_scores_gemma":[0.00008106096,0.0001285115,0.0002580871,0.0002143465,0.0002184119,0.0001719431,0.0001737563,0.0006144933,0.0003763095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003090509,"about_ca_system_score_gemma":0.0002495167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004587869,"about_ca_topic_score_gemma":0.0008401806,"domain_scores_codex":[0.9999127,0.000006965634,0.000006671098,0.00002480009,0.00002339375,0.00002539895],"domain_scores_gemma":[0.9999225,0.000004932846,0.00002363726,0.000008891181,0.000008777596,0.00003120897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001048886,0.00002931227,0.0002289515,0.00006593292,0.000007380768,0.00006597456,0.00001051873,0.00004853751,0.9983748,0.00009268772,0.0001732034,0.0007978192],"study_design_scores_gemma":[0.00004638898,0.0001931603,0.007419828,0.000009229259,0.00004612725,0.000470688,0.0000405042,0.001225503,0.9847504,0.00005649624,0.005735037,0.000006604093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924464,0.001802018,0.00243016,0.0002056235,0.00003978731,0.00002745234,0.0008816348,0.0002386879,0.001928274],"genre_scores_gemma":[0.993022,0.0008922387,0.001391927,0.00006835941,0.00001761559,0.00005870507,0.001439039,0.00005296873,0.003057055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001375396,"threshold_uncertainty_score":0.004601181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364335736577048,"score_gpt":0.294113562902237,"score_spread":0.2804702055364665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}