{"id":"W4403832002","doi":"10.1681/asn.2024dsw9s87d","title":"Defining Molecular Mechanisms in Antibody-Mediated Rejection Using Unbiased Proteomics in Donor-Specific Antibody-Positive and -Negative Recipients","year":2024,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Xenotransplantation and immune response","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital; University of Toronto","funders":"","keywords":"Antibody; Proteomics; Immunology; Computational biology; Medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005809264,0.0002372893,0.0002022534,0.0005924143,0.0001820429,0.0003726491,0.0001891156,0.0003352124,0.0004329174],"category_scores_gemma":[0.00028037,0.00009996082,0.0002104329,0.0002791471,0.0002487025,0.0002867053,0.0002553529,0.0001938531,0.0001489687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001594926,"about_ca_system_score_gemma":0.0001279308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002105148,"about_ca_topic_score_gemma":0.0002875468,"domain_scores_codex":[0.999811,0.0000313052,0.00001874676,0.0000475827,0.00005379345,0.00003763861],"domain_scores_gemma":[0.9998709,0.00002060351,0.00005207151,0.000009784246,0.0000204952,0.00002614328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001150814,0.0001077036,0.1430698,0.0001182783,0.0001250334,0.0003589399,0.0001172727,0.0001460143,0.8445006,0.0001716382,0.00008182268,0.01005211],"study_design_scores_gemma":[0.00003065558,0.0009373421,0.8921288,0.00002257327,0.0001729676,0.00224963,0.0002023297,0.001512106,0.1012202,0.0003208526,0.001191142,0.00001137681],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969892,0.001377862,0.001181425,0.00002187783,0.000005637462,0.00001391095,0.00011369,0.000009702472,0.0002867622],"genre_scores_gemma":[0.9979881,0.0005301578,0.001079954,0.00005279726,0.000008503851,0.0000158744,0.0001892252,0.000003296796,0.0001321945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005924143,"threshold_uncertainty_score":0.003072262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340566726037466,"score_gpt":0.3071882047674728,"score_spread":0.2937825375070982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}