{"id":"W4403833178","doi":"10.1681/asn.2024g2b9hn9b","title":"Senolytics (Dasatinib/Quercetin) Inhibit Hedgehog Interacting Protein (Hhip)-Mediated Tubular Senescence in Diabetic Kidney Disease","year":2024,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Dasatinib; Quercetin; Senescence; Cancer research; Disease; Medicine; Hedgehog signaling pathway; Kidney disease; Hedgehog; Diabetic nephropathy; Kidney; Chemistry; Pharmacology; Internal medicine; Biology; Cell biology; Biochemistry; Signal transduction; Imatinib; Antioxidant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300178,0.000248541,0.0003002698,0.0002588817,0.0001214177,0.0001124604,0.0001648784,0.000149267,0.001212874],"category_scores_gemma":[0.00008954159,0.00007570763,0.0001893896,0.000136189,0.0001710585,0.0001034134,0.0001332372,0.0003552491,0.0001705479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001161346,"about_ca_system_score_gemma":0.000202454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003242639,"about_ca_topic_score_gemma":0.0009447721,"domain_scores_codex":[0.9999417,0.00001356892,0.00000769007,0.000007535077,0.00001203248,0.00001738687],"domain_scores_gemma":[0.999952,0.000005597376,0.0000139371,0.000004639508,0.00000689668,0.00001697429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00126385,0.0003731505,0.0009489679,0.0002127764,0.00004730731,0.0000872903,0.00002149862,0.0001813177,0.9846752,0.0001427861,0.0002848062,0.01176097],"study_design_scores_gemma":[0.0008185226,0.01044416,0.02405728,0.00003248703,0.0001597079,0.001210293,0.00009847811,0.001470973,0.9551785,0.0001618577,0.006353728,0.00001400734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943136,0.002972072,0.0008225078,0.0001033609,0.00002503352,0.00005552129,0.000231625,0.0001009677,0.00137542],"genre_scores_gemma":[0.997347,0.00124688,0.000510659,0.000044911,0.000007468482,0.00002608846,0.00024182,0.000003822283,0.000571303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212874,"threshold_uncertainty_score":0.004057467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191674847689943,"score_gpt":0.2656059487940857,"score_spread":0.2536892003171862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}