{"id":"W4403833178","doi":"10.1681/asn.2024g2b9hn9b","title":"Senolytics (Dasatinib/Quercetin) Inhibit Hedgehog Interacting Protein (Hhip)-Mediated Tubular Senescence in Diabetic Kidney Disease","year":2024,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Dasatinib; Quercetin; Senescence; Cancer research; Disease; Medicine; Hedgehog signaling pathway; Kidney disease; Hedgehog; Diabetic nephropathy; Kidney; Chemistry; Pharmacology; Internal medicine; Biology; Cell biology; Biochemistry; Signal transduction; Imatinib; Antioxidant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00066215,0.0002147621,0.0004578646,0.00006874308,0.00006604226,0.00002120098,0.0004052844,0.00009423347,0.000007305726],"category_scores_gemma":[0.0009426631,0.0001628565,0.0004517302,0.0004108542,0.0006352941,0.00001089232,0.000280124,0.0005133503,0.000003692892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006550724,"about_ca_system_score_gemma":0.0004822984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002749607,"about_ca_topic_score_gemma":0.000004652819,"domain_scores_codex":[0.9981725,0.0003032118,0.0006501958,0.0002705579,0.0002538941,0.0003496939],"domain_scores_gemma":[0.9985684,0.0001665541,0.0006163013,0.0003031151,0.0001833747,0.0001622656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001575732,0.00007952441,0.00741228,0.0001401678,0.0002433049,0.00002949461,0.0007477917,0.0001632039,0.9843031,0.000004643482,0.00597056,0.0007483855],"study_design_scores_gemma":[0.004093118,0.004439845,0.1265335,0.004388912,0.000755023,0.0005254958,0.008504958,0.01157857,0.6756626,0.0007368656,0.1609989,0.001782124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911684,0.001290496,0.0004471289,0.006663181,0.000193401,0.000189126,0.00002012325,0.00001000847,0.00001808214],"genre_scores_gemma":[0.9942002,0.00034173,0.001434907,0.003524751,0.0003787398,0.000007877706,0.000005138339,0.00003442727,0.00007224987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3086404,"threshold_uncertainty_score":0.6641096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191674847689943,"score_gpt":0.2656059487940857,"score_spread":0.2536892003171862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}