{"id":"W4403833735","doi":"10.1681/asn.2024qdwvz5bg","title":"VALIANT: A Randomized, Multicenter, Double-Blind, Placebo (PBO)-Controlled, Phase 3 Trial of Pegcetacoplan for Patients with Native or Post-transplant Recurrent Glomerulopathy (C3G) or Primary Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)","year":2024,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Membranoproliferative glomerulonephritis; Medicine; Glomerulopathy; Placebo; Immune system; Double blind; Internal medicine; Immunology; Gastroenterology; Urology; Glomerulonephritis; Kidney; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001705493,0.001480917,0.001979019,0.0003454924,0.0004873874,0.001139565,0.0007906726,0.001563495,0.006414671],"category_scores_gemma":[0.001303217,0.0005999474,0.001324197,0.0003700926,0.001026563,0.0008810784,0.0003747811,0.002437771,0.0009400939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005443899,"about_ca_system_score_gemma":0.00137246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005332814,"about_ca_topic_score_gemma":0.001598516,"domain_scores_codex":[0.9995184,0.0002653431,0.00002391434,0.00008423404,0.00003642674,0.00007167691],"domain_scores_gemma":[0.9993458,0.0001487006,0.0002062435,0.00004279591,0.00004501604,0.0002114366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9735556,0.004824894,0.0005071334,0.0008358976,0.0006465492,0.00004137291,0.00005703077,0.0002671946,0.005134677,0.0001634677,0.001563026,0.01240309],"study_design_scores_gemma":[0.9701914,0.02748439,0.0007833277,0.00002729812,0.0001713838,0.00003176782,0.00001192263,0.0001318386,0.0003613238,0.00007751905,0.0007205597,0.000007360198],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749578,0.007646665,0.00144617,0.00110724,0.0006893421,0.006938088,0.002962552,0.0003653689,0.003886753],"genre_scores_gemma":[0.9723909,0.004143359,0.00372698,0.002268424,0.0005486594,0.009870435,0.002407095,0.00007426065,0.004569947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006414671,"threshold_uncertainty_score":0.02145922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756307641308051,"score_gpt":0.3113322149081922,"score_spread":0.2837691384951117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}