{"id":"W4403833735","doi":"10.1681/asn.2024qdwvz5bg","title":"VALIANT: A Randomized, Multicenter, Double-Blind, Placebo (PBO)-Controlled, Phase 3 Trial of Pegcetacoplan for Patients with Native or Post-transplant Recurrent Glomerulopathy (C3G) or Primary Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)","year":2024,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Membranoproliferative glomerulonephritis; Medicine; Glomerulopathy; Placebo; Immune system; Double blind; Internal medicine; Immunology; Gastroenterology; Urology; Glomerulonephritis; Kidney; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001475677,0.0005232294,0.003576338,0.0002293708,0.0002432356,0.00002905882,0.0007595943,0.0001599323,0.0002961016],"category_scores_gemma":[0.0002056811,0.000275611,0.002061004,0.0004532873,0.002096859,0.0002023258,0.000140488,0.0005471146,0.000004289471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001746101,"about_ca_system_score_gemma":0.0007650479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000115621,"about_ca_topic_score_gemma":0.0000468171,"domain_scores_codex":[0.9946878,0.001609626,0.002372809,0.0004236808,0.0003381234,0.0005679757],"domain_scores_gemma":[0.9913715,0.00364071,0.003546259,0.0004007325,0.000961235,0.000079639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9395537,0.002699954,0.0001073908,0.0005749462,0.01020035,0.00001234247,0.003647598,0.00001043026,0.03762361,0.00004466168,0.003485811,0.002039225],"study_design_scores_gemma":[0.9685548,0.01730883,0.0005244778,0.0007187344,0.00287569,0.0002494256,0.001730844,0.00008797941,0.001645981,0.00002187603,0.005953853,0.0003275054],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820545,0.004412631,0.0007398645,0.00176063,0.00133161,0.007451326,0.002193222,0.00002975195,0.00002650652],"genre_scores_gemma":[0.9957779,0.001245974,0.001024415,0.0008398692,0.0002147938,0.0004062087,0.0002394573,0.00005561131,0.0001957549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03597763,"threshold_uncertainty_score":0.9999696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756307641308051,"score_gpt":0.3113322149081922,"score_spread":0.2837691384951117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}