{"id":"W4403833990","doi":"10.1681/asn.2024cbzm75k9","title":"First-in-Class Phase 3 Clinical Trial Candidate Rilparencel Expresses Nephron Markers and Acquires Glomerular Epithelial and Tubular Features","year":2024,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Birth, Development, and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Nephron; Class (philosophy); Medicine; Pathology; Internal medicine; Biology; Urology; Cell biology; Renal function; Computer science; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009359555,0.0006270727,0.001276134,0.0001945804,0.0003282708,0.001131586,0.0006095067,0.0007619529,0.01208481],"category_scores_gemma":[0.0005479784,0.000211148,0.0008202153,0.0002004084,0.0003915489,0.0006785852,0.0002672758,0.00286978,0.002584846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005916494,"about_ca_system_score_gemma":0.001270701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005097417,"about_ca_topic_score_gemma":0.001878757,"domain_scores_codex":[0.9997604,0.00004432311,0.00001097675,0.00005878745,0.0000448233,0.00008062372],"domain_scores_gemma":[0.9996614,0.00003494144,0.00006261009,0.0000376478,0.00004421821,0.0001591516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2029095,0.03362641,0.01764673,0.004464899,0.003594436,0.0009753068,0.0004919801,0.005374926,0.3359709,0.002752601,0.08062404,0.3115682],"study_design_scores_gemma":[0.2941518,0.3737955,0.05194197,0.0004326749,0.003394887,0.00324203,0.0004181907,0.006451053,0.09166347,0.003192824,0.1711478,0.0001678614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947619,0.01041317,0.004702866,0.002739395,0.0007685704,0.003927162,0.01337772,0.001112062,0.01533993],"genre_scores_gemma":[0.9550119,0.00306878,0.005498489,0.003256782,0.0002173459,0.002935149,0.01414892,0.0002260585,0.01563655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01208481,"threshold_uncertainty_score":0.04042774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756885614155401,"score_gpt":0.3581210657519222,"score_spread":0.3305522096103682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}