{"id":"W4403834171","doi":"10.1681/asn.2024k1xwnxgq","title":"Successful Use of Eculizumab for Prevention of Atypical Hemolytic Uremic Syndrome Recurrence in a Pregnant Kidney Transplant Recipient with CFH Gene Mutation: A Case Report and Literature Review","year":2024,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakeshore General Hospital; McGill University","funders":"","keywords":"Atypical hemolytic uremic syndrome; Eculizumab; Medicine; Thrombotic microangiopathy; Renal transplant; Nephrology; Kidney; Internal medicine; Immunology; Gastroenterology; Intensive care medicine; Complement system; Antibody; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004379413,0.0001259689,0.0006731877,0.00006761374,0.00003073048,0.000005158635,0.0001539088,0.00006592586,0.0000148892],"category_scores_gemma":[0.00009761286,0.00007982286,0.0003335653,0.0003290157,0.0005037137,0.00009256023,0.00003713772,0.0002192141,1.126407e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004585082,"about_ca_system_score_gemma":0.000241447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004129519,"about_ca_topic_score_gemma":0.00001543859,"domain_scores_codex":[0.998394,0.0003197491,0.0008848505,0.0001773872,0.00007652901,0.0001474651],"domain_scores_gemma":[0.9980164,0.000297573,0.001244257,0.0002121177,0.0002003942,0.00002928322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.02461295,0.004180279,0.05413426,0.07178748,0.01519661,0.05028905,0.02392239,0.0003735956,0.6028175,0.0004273966,0.1238345,0.02842391],"study_design_scores_gemma":[0.00286116,0.005599174,0.02857517,0.05235105,0.001778627,0.8991426,0.0006221653,0.0001337908,0.004306747,0.0002518208,0.004125054,0.0002526745],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542468,0.04278298,0.0005903777,0.001540233,0.0001144482,0.0005575814,0.0001634552,0.000003572309,5.411145e-7],"genre_scores_gemma":[0.9924043,0.005659764,0.001543655,0.0003002309,0.00001221533,0.00002055637,0.00002680667,0.00000878773,0.00002362562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8488535,"threshold_uncertainty_score":0.3255082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966898907270643,"score_gpt":0.2890547252719565,"score_spread":0.26938573619925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}