{"id":"W4403845046","doi":"10.1186/s12974-024-03267-5","title":"Fenebrutinib, a Bruton’s tyrosine kinase inhibitor, blocks distinct human microglial signaling pathways","year":2024,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; F. Hoffmann-La Roche; Roche; U.S. Department of Defense","keywords":"Bruton's tyrosine kinase; Microglia; Neuroinflammation; Signal transduction; Biology; Cell biology; Chemokine; Tyrosine kinase; Immunology; Immune system; Inflammation; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000838979,0.0002116192,0.0003843405,0.0004495563,0.0001281877,0.0001914224,0.0001587829,0.0001181517,0.0001656871],"category_scores_gemma":[0.0004685954,0.0001725876,0.0002914487,0.0003517312,0.00008461091,0.0002981057,0.00007097749,0.0006536083,0.00005478362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003145846,"about_ca_system_score_gemma":0.002964047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002742209,"about_ca_topic_score_gemma":0.000006386467,"domain_scores_codex":[0.9973946,0.00009941866,0.0009994042,0.0002516949,0.0009133019,0.0003415579],"domain_scores_gemma":[0.9986189,0.000221119,0.0002872484,0.0002500523,0.0003649851,0.000257668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002955336,0.00009415938,0.00008543475,0.0004089401,0.00006841933,0.006156421,0.0004489776,0.00008886286,0.9848014,0.0001648669,0.001974225,0.00541282],"study_design_scores_gemma":[0.01154095,0.001752317,0.001218244,0.002281072,0.0003564565,0.01273924,0.00009333614,0.01809365,0.9413247,0.0006469956,0.009642693,0.0003103648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962662,0.0007894624,0.0002236217,0.0009480055,0.000719032,0.0002741695,0.00000786828,0.00007952422,0.0006921262],"genre_scores_gemma":[0.9960557,0.00003945297,0.0003066931,0.00003457401,0.002895748,0.000003628765,0.0000163991,0.00005389617,0.0005938767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04347666,"threshold_uncertainty_score":0.8226277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02960991530105403,"score_gpt":0.3030447887922316,"score_spread":0.2734348734911776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}