{"id":"W4403846057","doi":"10.1101/2024.10.27.620485","title":"PXGS: a Poly-Transgene Expression System based on Mutually Exclusive Splicing of Dscam","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Transgene; RNA splicing; Alternative splicing; Cell biology; Biology; Genetics; Computational biology; Computer science; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003923345,0.0005318066,0.0002488526,0.0004557606,0.0002296514,0.0003320441,0.0005425551,0.0003695113,0.002534542],"category_scores_gemma":[0.0001642459,0.0003750018,0.0003027,0.0002251236,0.0004542447,0.0003726729,0.0007078545,0.001015026,0.001399492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003123197,"about_ca_system_score_gemma":0.000261606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004531352,"about_ca_topic_score_gemma":0.0008010417,"domain_scores_codex":[0.999712,0.00004158145,0.00002645211,0.00009241116,0.0001000393,0.00002750815],"domain_scores_gemma":[0.9998698,0.00002698329,0.00002929047,0.0000377885,0.00001214249,0.00002386359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004063363,0.00001023407,0.00007663703,0.00002497995,0.000004282475,0.00004049544,0.00001392379,0.00008718609,0.9958163,0.0005847659,0.0001257042,0.003174907],"study_design_scores_gemma":[0.00002303079,0.00007613358,0.0006377789,0.000003932546,0.00001018171,0.0002351711,0.000005532387,0.001274926,0.9892293,0.0001377315,0.008359686,0.000006627819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5227599,0.001205708,0.4580518,0.0004145214,0.0003392299,0.0005667968,0.002274413,0.006577937,0.00780962],"genre_scores_gemma":[0.7212505,0.001387145,0.2405445,0.0001807588,0.00006707615,0.0006807783,0.005316217,0.001445343,0.02912772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002534542,"threshold_uncertainty_score":0.00847888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009301444530941054,"score_gpt":0.2360327098793965,"score_spread":0.2267312653484554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}