{"id":"W4403847662","doi":"10.1016/j.toxrep.2024.101790","title":"Lack of genotoxicity and subchronic toxicity in safety assessment studies of Akkermansia muciniphila formulation","year":2024,"lang":"en","type":"article","venue":"Toxicology Reports","topic":"Pharmaceutical and Antibiotic Environmental Impacts","field":"Environmental Science","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Intertek (Canada)","funders":"","keywords":"Genotoxicity; Akkermansia muciniphila; Toxicity; Pharmacology; Traditional medicine; Chemistry; Toxicology; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000612538,0.0001239573,0.0003093289,0.00004697944,0.00003315568,0.000004271476,0.00004938778,0.0000888714,0.000389054],"category_scores_gemma":[0.00004253805,0.000103018,0.00004571297,0.000162973,0.0004433267,0.0001701603,0.0002129238,0.0001421391,0.000006437053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457851,"about_ca_system_score_gemma":0.00002121313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003737908,"about_ca_topic_score_gemma":0.0001072625,"domain_scores_codex":[0.9986789,0.00006585338,0.000550872,0.0003003323,0.0001870452,0.0002169554],"domain_scores_gemma":[0.9995215,0.0001167782,0.0001358752,0.0001516891,0.0000035976,0.00007055057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002632684,0.0002804354,0.3766773,0.0002045587,0.00005381901,0.0002704487,0.0004791771,0.001001046,0.6160241,0.0004214711,0.0001167422,0.004444582],"study_design_scores_gemma":[0.0002101188,0.0002120525,0.8803346,0.00007771233,0.0000385028,0.000152734,0.00006374448,0.002272569,0.1135708,0.002495405,0.0004449834,0.0001268207],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958012,0.0005789219,0.00008535892,0.0003321318,0.0001237247,0.0002515038,0.000005092271,0.00001715079,0.002804989],"genre_scores_gemma":[0.9990477,0.0003951623,0.0003038988,0.0001117208,0.00001108749,0.000003043724,0.000003913937,0.000007853905,0.0001156199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5036573,"threshold_uncertainty_score":0.4259869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06489324645293737,"score_gpt":0.3895066460175514,"score_spread":0.324613399564614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}