{"id":"W4403847662","doi":"10.1016/j.toxrep.2024.101790","title":"Lack of genotoxicity and subchronic toxicity in safety assessment studies of Akkermansia muciniphila formulation","year":2024,"lang":"en","type":"article","venue":"Toxicology Reports","topic":"Pharmaceutical and Antibiotic Environmental Impacts","field":"Environmental Science","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Intertek (Canada)","funders":"","keywords":"Genotoxicity; Akkermansia muciniphila; Toxicity; Pharmacology; Traditional medicine; Chemistry; Toxicology; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004264645,0.0004073818,0.0002403755,0.0002650468,0.0002497613,0.0002966868,0.000207831,0.0005605171,0.002084604],"category_scores_gemma":[0.0006191531,0.0001212257,0.0003750488,0.0001922986,0.0003170134,0.0002318438,0.0002602529,0.0005090255,0.0003223944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001538065,"about_ca_system_score_gemma":0.0003406276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009195971,"about_ca_topic_score_gemma":0.001571459,"domain_scores_codex":[0.9994971,0.0001363388,0.00005578684,0.0000997443,0.00016758,0.00004361392],"domain_scores_gemma":[0.9993764,0.000155834,0.0001568661,0.00009992789,0.0001644475,0.00004660962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001479956,0.00009393295,0.0006960767,0.0001290391,0.000009448473,0.00009769922,0.00004777892,0.000059199,0.9950237,0.00003597912,0.00005044227,0.003608663],"study_design_scores_gemma":[0.000007625432,0.004345804,0.01201912,0.00003577417,0.00004519278,0.0004823838,0.0001127152,0.0001488633,0.9790984,0.00004413966,0.003652056,0.000007996347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864905,0.0023248,0.004932802,0.0001910766,0.00009157872,0.0002430807,0.0008202017,0.00007441556,0.0048314],"genre_scores_gemma":[0.9837105,0.001082578,0.006322467,0.0001246059,0.00001777749,0.0001975399,0.001010124,0.00001712905,0.007517235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002084604,"threshold_uncertainty_score":0.006973743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06489324645293737,"score_gpt":0.3895066460175514,"score_spread":0.324613399564614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}