{"id":"W4403851941","doi":"10.1038/s41375-024-02400-w","title":"Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines","year":2024,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital Maisonneuve-Rosemont; Université de Montréal; University of British Columbia; Centre hospitalier de l'Université Laval; Discovery Centre; McGill University; McGill University Health Centre; Institute for Research in Immunology and Cancer; BC Cancer Agency; Centre hospitalier universitaire de Québec; IONICS Mass Spectrometry (Canada); Centre Hospitalier Universitaire Sainte-Justine","funders":"CIHR Skin Research Training Centre; Fonds de Recherche du Québec - Santé; CHU Sainte-Justine Foundation; Cancer Research Society; Terry Fox Research Institute; Université de Montréal; Canadian Cancer Society Research Institute; Terry Fox Foundation; National Institutes of Health; Children's Hospital Foundation; Government of Canada; National Cancer Institute; Molson Foundation; Canadian Institutes of Health Research; JW and HM Goodman Family Foundation","keywords":"Leukemia; Human cell; Primary (astronomy); Cancer research; Medicine; Cell culture; Biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0008078488,0.001015865,0.001946111,0.001052376,0.0004056593,0.0002224201,0.0006972495,0.0007254386,0.0002612166],"category_scores_gemma":[0.00007316338,0.0009514513,0.0004914636,0.001282975,0.0007592266,0.0004081472,0.0006681846,0.002337885,0.0001385624],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007882524,"about_ca_system_score_gemma":0.004127687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001226606,"about_ca_topic_score_gemma":0.00006820256,"domain_scores_codex":[0.9944776,0.0002080837,0.001417246,0.001508725,0.001061347,0.001327034],"domain_scores_gemma":[0.9968507,0.0004562282,0.0002889394,0.001219131,0.0004296668,0.0007553303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000411038,0.00007998,0.0008165133,0.002747807,0.001134919,0.001485003,0.00265863,0.0005860861,0.9647869,0.001489623,0.0213577,0.00244578],"study_design_scores_gemma":[0.01380181,0.002495653,0.02149301,0.003309999,0.002311776,0.001222398,0.001550978,0.04363012,0.8902715,0.0005103402,0.0168902,0.002512242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691286,0.003862983,0.001878546,0.0001742125,0.0002034746,0.001341126,0.0001357753,0.0006770015,0.02259828],"genre_scores_gemma":[0.9764838,0.0003917864,0.007668818,0.0004581894,0.0007398484,0.0001334938,0.0007926991,0.0002625829,0.01306877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07451545,"threshold_uncertainty_score":0.9999638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03877647701958165,"score_gpt":0.3104672159798481,"score_spread":0.2716907389602665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}