{"id":"W4403851941","doi":"10.1038/s41375-024-02400-w","title":"Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines","year":2024,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital Maisonneuve-Rosemont; Université de Montréal; University of British Columbia; Centre hospitalier de l'Université Laval; Discovery Centre; McGill University; McGill University Health Centre; Institute for Research in Immunology and Cancer; BC Cancer Agency; Centre hospitalier universitaire de Québec; IONICS Mass Spectrometry (Canada); Centre Hospitalier Universitaire Sainte-Justine","funders":"CIHR Skin Research Training Centre; Fonds de Recherche du Québec - Santé; CHU Sainte-Justine Foundation; Cancer Research Society; Terry Fox Research Institute; Université de Montréal; Canadian Cancer Society Research Institute; Terry Fox Foundation; National Institutes of Health; Children's Hospital Foundation; Government of Canada; National Cancer Institute; Molson Foundation; Canadian Institutes of Health Research; JW and HM Goodman Family Foundation","keywords":"Leukemia; Human cell; Primary (astronomy); Cancer research; Medicine; Cell culture; Biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004169458,0.0004473261,0.0004820849,0.0004171702,0.0001460042,0.0003757618,0.0002181992,0.0002503567,0.001246558],"category_scores_gemma":[0.000358652,0.0001085617,0.0002821798,0.0003734916,0.0001962951,0.000159996,0.0002973378,0.0004615528,0.0003862593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00022948,"about_ca_system_score_gemma":0.0002828244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005899424,"about_ca_topic_score_gemma":0.001685834,"domain_scores_codex":[0.9995153,0.0001025015,0.0000505602,0.00008286216,0.0002078497,0.00004102588],"domain_scores_gemma":[0.9998072,0.00005535277,0.0000276859,0.00003440178,0.00005209213,0.00002336011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001186065,0.0001224888,0.0006612497,0.00007231248,0.0000247001,0.00005190458,0.00001436299,0.000402946,0.9932202,0.00007148623,0.0001340928,0.005105491],"study_design_scores_gemma":[0.00004596257,0.0018316,0.004465333,0.000009999232,0.00005896586,0.0004473764,0.00003616159,0.0008246088,0.9850273,0.00007500483,0.007169731,0.000007892765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9536624,0.006032595,0.02906739,0.0002546693,0.00007096863,0.0006593083,0.005251988,0.0004128235,0.004587941],"genre_scores_gemma":[0.9568279,0.007055542,0.01925078,0.0002895303,0.00002932874,0.0003171806,0.0115135,0.00007134708,0.004644813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246558,"threshold_uncertainty_score":0.004170179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03877647701958165,"score_gpt":0.3104672159798481,"score_spread":0.2716907389602665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}