{"id":"W4403852388","doi":"10.1172/jci.insight.185952","title":"ASCL1 regulates and cooperates with FOXA2 to drive terminal neuroendocrine phenotype in prostate cancer","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Prostate Cancer Foundation","keywords":"Prostate cancer; Phenotype; Terminal (telecommunication); FOXA2; Cancer research; Prostate; Internal medicine; Neuroendocrine differentiation; Cancer; Biology; Medicine; Transcription factor; Gene; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002278637,0.0001269031,0.00009442164,0.00007229839,0.0000287506,0.00005983653,0.00004906228,0.00002519678,0.00002708052],"category_scores_gemma":[0.000007768783,0.00009930396,0.00001597108,0.0001617114,0.00004652817,0.00001183454,0.00002699149,0.00006544897,0.000007091765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001567016,"about_ca_system_score_gemma":0.00005068044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006775551,"about_ca_topic_score_gemma":0.0004726309,"domain_scores_codex":[0.9992993,0.00002237657,0.0001168859,0.0003289567,0.00007705913,0.0001553798],"domain_scores_gemma":[0.9997523,0.000005466584,0.00001359368,0.0001253147,0.00004457509,0.00005873716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002252666,0.00003228676,0.009901774,0.00007627934,0.00003385243,0.00009327217,0.0004618576,0.0005648014,0.9800938,0.0001996401,0.001124685,0.007192483],"study_design_scores_gemma":[0.0008950158,0.0008982542,0.1132977,0.0002067604,0.00003456468,0.00009335213,0.00005271238,0.0008262881,0.5956889,0.00005854599,0.2875287,0.0004191718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964881,0.001873404,0.00004074863,0.0009173749,0.0001274353,0.0002526252,0.0000197064,0.00002318116,0.0002574568],"genre_scores_gemma":[0.9975627,0.0002141614,0.0001497653,0.0002014485,0.00008027705,0.0000486299,0.00005720442,0.00002409614,0.001661728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3844048,"threshold_uncertainty_score":0.4049498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006762783669714701,"score_gpt":0.2440702518550957,"score_spread":0.237307468185381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}