{"id":"W4403859802","doi":"10.1182/bloodadvances.2024014555","title":"Cancer cachexia and weight loss before CAR T-cell therapy for lymphoma are independently associated with poor outcomes","year":2024,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Janssen Biotech; Genentech; National Institutes of Health; Swedish Orphan Biovitrum; Omeros Corporation; Incyte; BeiGene; Angiocrine Bioscience; Parker Institute for Cancer Immunotherapy; Servier; Memorial Sloan-Kettering Cancer Center; National Cancer Institute; Medpace; Celgene; Gilead Sciences; Sanofi; Pfizer; Seres Therapeutics; Amgen","keywords":"Medicine; Weight loss; Cachexia; Internal medicine; Cancer; Lymphoma; Oncology; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003883498,0.0001871305,0.0002341389,0.0004143206,0.000245913,0.0005457586,0.0002164336,0.0002605047,0.001737258],"category_scores_gemma":[0.001480099,0.0001348282,0.0003175245,0.0006109046,0.0002344658,0.0003053041,0.0003356669,0.0005857317,0.0001950349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000192087,"about_ca_system_score_gemma":0.0003191205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213506,"about_ca_topic_score_gemma":0.001929531,"domain_scores_codex":[0.9997665,0.00005285846,0.00002906798,0.0000501792,0.00005182304,0.00004949826],"domain_scores_gemma":[0.9982261,0.0002078675,0.001023065,0.0001021842,0.0001149748,0.0003259102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000146772,0.00001790525,0.9986014,0.00000491985,0.00003409755,0.00005078286,0.000008706046,0.00003014153,0.0003654827,0.000005124184,0.00004821065,0.0006864617],"study_design_scores_gemma":[0.000005177297,0.00009162242,0.9989754,0.000003597938,0.0000366897,0.0003260784,0.00003659479,0.0002103376,0.000174561,0.00001244091,0.0001252804,0.000002328544],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993479,0.0002090722,0.00008619755,0.00003356294,0.000005122032,0.000003189643,0.0001263999,0.000003143074,0.0001853249],"genre_scores_gemma":[0.9996914,0.00004489434,0.0000364327,0.00001161096,0.00000743857,0.000002017326,0.0001415141,0.000001270722,0.00006347519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737258,"threshold_uncertainty_score":0.005811751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509300459943864,"score_gpt":0.307879510756468,"score_spread":0.2927865061570293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}