{"id":"W4403859802","doi":"10.1182/bloodadvances.2024014555","title":"Cancer cachexia and weight loss before CAR T-cell therapy for lymphoma are independently associated with poor outcomes","year":2024,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Janssen Biotech; Genentech; National Institutes of Health; Swedish Orphan Biovitrum; Omeros Corporation; Incyte; BeiGene; Angiocrine Bioscience; Parker Institute for Cancer Immunotherapy; Servier; Memorial Sloan-Kettering Cancer Center; National Cancer Institute; Medpace; Celgene; Gilead Sciences; Sanofi; Pfizer; Seres Therapeutics; Amgen","keywords":"Medicine; Weight loss; Cachexia; Internal medicine; Cancer; Lymphoma; Oncology; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001923942,0.00027573,0.0004752714,0.0001353597,0.0001104114,0.00007344539,0.0001252728,0.0001255787,0.000257801],"category_scores_gemma":[0.00003772872,0.0001788019,0.0001207274,0.0002775801,0.0001427118,0.0001853134,0.00003026776,0.0001725926,0.000004135397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001190978,"about_ca_system_score_gemma":0.0002560641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001085165,"about_ca_topic_score_gemma":0.0009002002,"domain_scores_codex":[0.9983109,0.00003572378,0.0002091774,0.0004946584,0.0004955708,0.0004540344],"domain_scores_gemma":[0.9991699,0.0002060956,0.00007883934,0.0002184318,0.0001593377,0.0001674079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009615923,0.0006055286,0.8781882,0.0005294651,0.00156751,0.0004202147,0.0009172582,0.000006674694,0.01055753,0.00007141828,0.0004244955,0.1057501],"study_design_scores_gemma":[0.04243794,0.004586797,0.5293767,0.001778328,0.001213202,0.0002360107,0.001319638,0.0004205951,0.1211195,0.001177499,0.2951421,0.001191719],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9481884,0.04766377,0.00001410952,0.001934208,0.0002215439,0.001017212,0.0001910392,0.0001471352,0.0006226431],"genre_scores_gemma":[0.9715767,0.004548353,0.0001586721,0.0004366019,0.0002751831,0.0003383022,0.00004740751,0.00009286165,0.02252594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3488115,"threshold_uncertainty_score":0.729133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509300459943864,"score_gpt":0.307879510756468,"score_spread":0.2927865061570293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}