{"id":"W4403860183","doi":"10.1016/j.urolonc.2024.09.030","title":"Bempegaldesleukin plus nivolumab in first-line advanced/metastatic urothelial carcinoma: Results from a phase II single-arm study (PIVOT-10)","year":2024,"lang":"en","type":"article","venue":"Urologic Oncology Seminars and Original Investigations","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Metastatic Urothelial Carcinoma; Nivolumab; Urothelial carcinoma; First line; Oncology; Internal medicine; Urology; Cancer; Bladder cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001662192,0.001502133,0.002645299,0.0004086683,0.0003215389,0.001559155,0.0009980652,0.001220187,0.002422733],"category_scores_gemma":[0.0008585169,0.0005943708,0.002451803,0.0004234563,0.001053357,0.001164527,0.0003327178,0.00385516,0.0007896816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001301145,"about_ca_system_score_gemma":0.001494892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001920686,"about_ca_topic_score_gemma":0.005746981,"domain_scores_codex":[0.9995296,0.0001815131,0.00001895539,0.00008501823,0.00004357901,0.0001413437],"domain_scores_gemma":[0.9993711,0.0001157088,0.00009905219,0.00005145635,0.00003896532,0.0003237304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.79158,0.03411119,0.004403769,0.00196953,0.003666753,0.0001336424,0.0002768852,0.003415281,0.02234073,0.000239612,0.003719792,0.1341427],"study_design_scores_gemma":[0.6079925,0.3687778,0.01444166,0.0001064751,0.001750514,0.0001771794,0.0001208254,0.001225224,0.00280135,0.000207941,0.002338826,0.00005969064],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902323,0.00600788,0.0003617055,0.0004054297,0.0002784425,0.0006068731,0.0009631815,0.00008650997,0.001057607],"genre_scores_gemma":[0.9876138,0.004792125,0.001149656,0.0008924996,0.0002088669,0.0006656358,0.001854285,0.00004698742,0.002776171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002645299,"threshold_uncertainty_score":0.009440482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05315875934705231,"score_gpt":0.3462873890793242,"score_spread":0.2931286297322718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}