{"id":"W4403872180","doi":"10.1038/s42003-024-07100-w","title":"Two ubiquitous aldo-keto reductases in the genus Papaver support a patchwork model for morphine pathway evolution","year":2024,"lang":"en","type":"article","venue":"Communications Biology","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor; Aptose Biosciences (Canada); University of Calgary","funders":"Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Papaver; Genus; Morphine; Biology; Botany; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003984443,0.0001544288,0.0001449024,0.00007849881,0.0001616798,0.00002511603,0.0007674227,0.000150836,0.00001113584],"category_scores_gemma":[0.00008300608,0.0001171213,0.0001119272,0.000191969,0.000227893,0.000006609641,0.0002818824,0.0001740943,0.00001789656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003505265,"about_ca_system_score_gemma":0.0002203585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007599274,"about_ca_topic_score_gemma":0.0003658994,"domain_scores_codex":[0.9989288,0.0001709282,0.0002767476,0.0003180661,0.00004118606,0.0002643131],"domain_scores_gemma":[0.9983209,0.00009650057,0.0000504935,0.001428867,0.00006751719,0.00003573244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003127067,0.001114509,0.001796486,0.0001458978,0.0004852638,0.0000208887,0.001934216,0.001398626,0.6376379,0.2392582,0.04649331,0.06940199],"study_design_scores_gemma":[0.00190799,0.001086788,0.0004816815,0.000101549,0.0001984949,0.0004082608,0.001003124,0.07358059,0.02392223,0.0565831,0.8397361,0.000990059],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8984123,0.04998422,0.03158541,0.01288102,0.0005581173,0.001877135,0.001184241,0.0001223132,0.003395209],"genre_scores_gemma":[0.9911276,0.001583082,0.003303685,0.0003943667,0.000232971,0.0004796522,0.002533852,0.00002282345,0.0003219954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7932428,"threshold_uncertainty_score":0.477607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03824905733708508,"score_gpt":0.3308390670519077,"score_spread":0.2925900097148226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}