{"id":"W4403876530","doi":"10.1021/acsinfecdis.4c00721","title":"Local Delivery of Exosomes and Antibiotics in Hydroxyapatite-Based Nanocement for Osteomyelitis Management","year":2024,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Orthopedic Infections and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Family Medicine","funders":"Ministry of Education, India; Science and Engineering Research Board; Indian Council of Medical Research; Department of Science and Technology, Ministry of Science and Technology, India; Indian Institute of Technology Kanpur","keywords":"Periosteum; Osteomyelitis; Drug delivery; Microvesicles; Bone healing; In vivo; Debridement (dental); Soft tissue; Medicine; Antibiotics; Biomedical engineering; Chemistry; Pathology; Surgery; Microbiology; Biology; Biotechnology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944958,0.0002222682,0.0002773336,0.0002228265,0.0001389312,0.0003568309,0.0001627231,0.0004111653,0.0004394655],"category_scores_gemma":[0.0001614971,0.0001147619,0.0003391288,0.00009780686,0.0002075686,0.0003973581,0.0003248645,0.0003322531,0.0001184057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001682615,"about_ca_system_score_gemma":0.0002102827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002452864,"about_ca_topic_score_gemma":0.0005626493,"domain_scores_codex":[0.9998716,0.00002323118,0.0000119757,0.000025863,0.00003827987,0.00002914958],"domain_scores_gemma":[0.9999319,0.00001482905,0.00002259039,0.000006023606,0.00001183522,0.0000127824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001225628,0.00004981512,0.0002709992,0.0002476797,0.00001546852,0.0002216358,0.00003246147,0.0003110729,0.9881803,0.0001818635,0.00008968278,0.0102766],"study_design_scores_gemma":[0.00003200556,0.0007347108,0.001398146,0.00002788148,0.00005167847,0.0003955151,0.00005885589,0.002079878,0.9908231,0.00007421954,0.004309307,0.0000146401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643178,0.01487493,0.01848373,0.0002549296,0.0001427871,0.0001350227,0.0001143704,0.0001274529,0.001548993],"genre_scores_gemma":[0.9869835,0.00332655,0.008339733,0.00008580091,0.00002825116,0.00006705693,0.0000481874,0.00001102083,0.001109915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004394655,"threshold_uncertainty_score":0.001470149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00660576528935345,"score_gpt":0.2568613293923691,"score_spread":0.2502555641030156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}