{"id":"W4403882231","doi":"10.1002/mco2.777","title":"Targeting immunosenescence for improved tumor immunotherapy","year":2024,"lang":"en","type":"review","venue":"MedComm","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"CAE (Canada)","funders":"Henan Provincial Science and Technology Research Project","keywords":"Immunosenescence; Immunotherapy; Immunology; Immune system; Cancer immunotherapy; Cancer; Biology; Tumor microenvironment; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001064891,0.001107882,0.002854728,0.0004405048,0.0004946807,0.0001377138,0.001302991,0.0008437047,0.0005759056],"category_scores_gemma":[0.0002162138,0.0008131355,0.001735284,0.000425856,0.0003150972,0.0001282949,0.0002220335,0.001325561,0.002075715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001986437,"about_ca_system_score_gemma":0.0005811738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005828241,"about_ca_topic_score_gemma":0.000001540185,"domain_scores_codex":[0.9958801,0.000694929,0.001445805,0.0008761168,0.00004888798,0.001054109],"domain_scores_gemma":[0.9972365,0.0009734467,0.0005813428,0.001075498,0.0001077256,0.00002548191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000265265,0.0001089903,8.074707e-8,0.006570383,0.001938645,0.000006985304,0.0001663324,5.043499e-8,0.01373781,0.0001760812,0.01557969,0.9614497],"study_design_scores_gemma":[0.000888809,0.0002815351,2.787258e-7,0.007193971,0.0009156273,0.0002482616,0.00005344485,0.000002423696,0.0007745945,0.00007391667,0.9886634,0.0009037903],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000004308486,0.9902874,0.0003267678,0.00008340263,0.00591971,0.002447503,0.000388457,0.0003936469,0.0001487801],"genre_scores_gemma":[0.000006353286,0.9800121,0.0002783715,0.0002005469,0.0001989275,0.001215213,0.001198736,0.0003177317,0.01657208],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9730837,"threshold_uncertainty_score":0.999432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02840585044387421,"score_gpt":0.3214652731432375,"score_spread":0.2930594226993633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}