{"id":"W4403882231","doi":"10.1002/mco2.777","title":"Targeting immunosenescence for improved tumor immunotherapy","year":2024,"lang":"en","type":"review","venue":"MedComm","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"CAE (Canada)","funders":"Henan Provincial Science and Technology Research Project","keywords":"Immunosenescence; Immunotherapy; Immunology; Immune system; Cancer immunotherapy; Cancer; Biology; Tumor microenvironment; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004927827,0.0006870083,0.0009955287,0.001591464,0.0002655154,0.0009134724,0.0007289978,0.00120312,0.003260689],"category_scores_gemma":[0.0004970173,0.0002393973,0.0005064075,0.001036205,0.0004221564,0.001324252,0.0006482231,0.002193945,0.001721926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006981925,"about_ca_system_score_gemma":0.0008263958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004335391,"about_ca_topic_score_gemma":0.0009713021,"domain_scores_codex":[0.9998055,0.00003457394,0.00001912117,0.00003064358,0.00007777349,0.00003236804],"domain_scores_gemma":[0.9998493,0.00006272399,0.00002087257,0.000006675944,0.00004127325,0.00001917264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008437566,0.0001347359,0.0002130548,0.01961275,0.00009246919,0.0003052655,0.00009522187,0.0007501235,0.01251698,0.01767204,0.04566805,0.9028549],"study_design_scores_gemma":[0.00001068505,0.00008917943,0.0003972769,0.001415819,0.00004933159,0.0006667146,0.0000389021,0.0001532756,0.001844955,0.00304938,0.9922714,0.00001296762],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000233957,0.9968334,0.0004313782,0.0004592765,0.0004352338,0.000008073413,0.00001938574,0.00001531644,0.001564001],"genre_scores_gemma":[0.001932849,0.995892,0.0003641875,0.0003277265,0.0002598369,0.00001386059,0.00003540449,0.000002558568,0.001171491],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003260689,"threshold_uncertainty_score":0.01090813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02840585044387421,"score_gpt":0.3214652731432375,"score_spread":0.2930594226993633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}