{"id":"W4403882246","doi":"10.1038/s41598-024-77056-8","title":"Positions of cysteine residues reveal local clusters and hidden relationships to Sequons and Transmembrane domains in Human proteins","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Transmembrane protein; Cysteine; Transmembrane domain; Computational biology; Biology; Bioinformatics; Chemistry; Amino acid; Genetics; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001615629,0.0001338894,0.0001651621,0.0006417408,0.0001850826,0.0002530582,0.0001378552,0.0002464055,0.0006804302],"category_scores_gemma":[0.0003785482,0.000091306,0.0001378175,0.0008009372,0.0002424091,0.0002766802,0.0001923346,0.000157877,0.0002272257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001389112,"about_ca_system_score_gemma":0.0001447867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005076963,"about_ca_topic_score_gemma":0.000781785,"domain_scores_codex":[0.9999002,0.00001240449,0.000007621517,0.00004374159,0.00002199482,0.00001391421],"domain_scores_gemma":[0.9997433,0.00005148701,0.000099087,0.00003604715,0.00003201248,0.00003805865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000436704,0.00003172213,0.03596935,0.0001958076,0.0000538454,0.0006082581,0.0003917723,0.001320853,0.9369632,0.001439391,0.0002493103,0.02233981],"study_design_scores_gemma":[0.00003692613,0.0004646778,0.586616,0.00005700705,0.0003188523,0.004634966,0.0008687594,0.02021276,0.3681717,0.006854214,0.01168957,0.00007459695],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944375,0.001072867,0.003442164,0.0000337485,0.000007365555,0.000004595122,0.0002136118,0.00004850347,0.0007397279],"genre_scores_gemma":[0.9960283,0.0002798899,0.003122395,0.00001302274,0.000008707073,0.000003880221,0.0002277391,0.000007854536,0.0003081803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006804302,"threshold_uncertainty_score":0.002276242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405097606464796,"score_gpt":0.2549657212225165,"score_spread":0.2409147451578686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}