{"id":"W4403904412","doi":"10.1016/j.isci.2024.111244","title":"CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Acetyltransferases; Lysine; Human immunodeficiency virus (HIV); Histone Acetyltransferases; Chemistry; Biology; Virology; Cell biology; Acetylation; Computational biology; Molecular biology; Biochemistry; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001767515,0.0001167215,0.0001321412,0.0002074143,0.0001058457,0.00004816472,0.0001748296,0.00008700888,0.0009341838],"category_scores_gemma":[0.0000326947,0.00008254315,0.000047339,0.0005373558,0.0002343427,0.0001914148,0.00006597962,0.0002225104,0.005323271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005015694,"about_ca_system_score_gemma":0.0001069181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007510123,"about_ca_topic_score_gemma":0.00005314243,"domain_scores_codex":[0.9989278,0.00009988637,0.000155697,0.0003498594,0.0000620031,0.000404811],"domain_scores_gemma":[0.9996588,0.0001025582,0.00001058545,0.0001706493,0.00002183126,0.00003559166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002364655,0.0001195811,0.002190997,0.00001773118,0.00001006155,0.00009789268,0.0004153612,0.00001717845,0.9880581,0.00004511298,0.002775083,0.006229258],"study_design_scores_gemma":[0.0005683326,0.0001302344,0.007244429,0.000160741,0.000006044195,0.00002340302,0.00004362605,0.00002426095,0.9713523,0.00004714883,0.02029134,0.0001081557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910898,0.005666847,0.0003492279,0.0006578385,0.0003178467,0.0002090968,0.00009475427,0.0001069732,0.001507665],"genre_scores_gemma":[0.9956774,0.0002414149,0.00006114584,0.00003727414,0.00001125217,0.00002728447,0.00007011696,0.000006910889,0.003867256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01751625,"threshold_uncertainty_score":0.9999791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369792916457851,"score_gpt":0.2637488462974376,"score_spread":0.250050917132859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}