{"id":"W4403904791","doi":"10.1016/s1473-3099(24)00598-x","title":"Predictable excess hepatotoxicity in the SimpliciTB trial","year":2024,"lang":"en","type":"letter","venue":"The Lancet Infectious Diseases","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001866128,0.000652553,0.0008897911,0.0002535585,0.0007518153,0.0003018057,0.001286829,0.001566188,0.0006267844],"category_scores_gemma":[0.0003214667,0.0004034186,0.0004320611,0.0008059908,0.0003804313,0.0001798706,0.0002165395,0.009241401,0.000661156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000282867,"about_ca_system_score_gemma":0.0002724646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004931184,"about_ca_topic_score_gemma":0.0002632691,"domain_scores_codex":[0.9936861,0.003302854,0.0006422568,0.0007097289,0.0005411716,0.001117824],"domain_scores_gemma":[0.9965346,0.002077285,0.0003005884,0.0009080726,0.00007223535,0.0001072537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002308055,0.000401604,0.00317488,0.0006016216,0.0003471031,0.0004235991,0.00067847,0.0002182169,0.00003751186,0.0002937903,0.9893022,0.002213007],"study_design_scores_gemma":[0.008996157,0.0002783528,0.000500257,0.0001055839,0.000723013,0.00009458837,0.00004294392,0.0005500611,0.0001448265,0.01538573,0.9726673,0.0005111875],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.308915,0.003328705,0.00004033085,0.6139479,0.01547358,0.008402338,0.002607236,0.00163189,0.04565307],"genre_scores_gemma":[0.427494,0.0006549092,8.15349e-7,0.5430827,0.02524661,0.002162833,0.0002732753,0.00008114475,0.001003779],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.118579,"threshold_uncertainty_score":0.9998417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1558066376318981,"score_gpt":0.426089314106727,"score_spread":0.2702826764748288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}