{"id":"W4403909260","doi":"10.1016/j.clbc.2024.10.017","title":"Another Biosignature for Ductal Carcinoma In Situ—Have We Moved the Needle?","year":2024,"lang":"en","type":"letter","venue":"Clinical Breast Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; In situ; Ductal carcinoma; Breast cancer; Carcinoma in situ; Surgery; Pathology; Carcinoma; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002400532,0.0006014456,0.0006757521,0.00007023334,0.00008948494,0.00005982959,0.0005382864,0.001575456,0.00008805718],"category_scores_gemma":[0.00005834709,0.0003987825,0.0007042679,0.0001441682,0.0004263633,0.0000043063,0.0002945677,0.001454413,0.00003084917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001331971,"about_ca_system_score_gemma":0.0003660023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002319306,"about_ca_topic_score_gemma":0.0006746873,"domain_scores_codex":[0.9971486,0.0001493516,0.0006398284,0.001198799,0.0002294879,0.0006339698],"domain_scores_gemma":[0.9985952,0.0002282728,0.0002097274,0.0007631751,0.000144665,0.00005897147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003942359,0.00007319112,0.008964578,0.0001678877,0.0006595826,0.00008168751,0.00008017643,0.000003709329,0.0004800779,0.000005342029,0.9840398,0.005049746],"study_design_scores_gemma":[0.001656099,0.0001162024,0.03390279,0.0002584904,0.0003908261,0.00008170102,0.00007561324,0.00001211412,0.0005115791,0.0002187542,0.9621989,0.0005769506],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.009565003,0.02589742,0.00001868134,0.9562356,0.003268624,0.00105181,0.003255519,0.00003588729,0.0006714872],"genre_scores_gemma":[0.2758659,0.002794581,0.00008190739,0.6775494,0.03375329,0.001628324,0.0009507486,0.0002960467,0.007079807],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2786862,"threshold_uncertainty_score":0.9998464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03111023548600697,"score_gpt":0.3331387168952305,"score_spread":0.3020284814092236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}