{"id":"W4403916378","doi":"10.1093/jac/dkae388","title":"Establishment of a diverse pheno-genotypic challenge set of <i>Klebsiella pneumoniae</i> and <i>Pseudomonas aeruginosa</i> suitable for use in the murine pneumonia model","year":2024,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Biomedical Advanced Research and Development Authority; Novo Nordisk Fonden; Novo Nordisk; Bundesministerium für Bildung und Forschung; Public Health Agency of Canada; Department of Health and Social Care; Wellcome Trust; Public Health Agency; Wellcome; Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator; Bill and Melinda Gates Foundation; Pfizer; National Institutes of Health; Shionogi; U.S. Department of Health and Human Services; Administration for Strategic Preparedness and Response","keywords":"Pseudomonas aeruginosa; Klebsiella pneumoniae; Microbiology; Biology; Streptococcus pneumoniae; Pneumonia; Klebsiella pneumonia; Tobramycin; Antibiotics; Bacteria; Medicine; Gentamicin; Escherichia coli; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001463101,0.001068109,0.0008531319,0.0009086689,0.000475354,0.0006706358,0.0007249785,0.0008477245,0.001346301],"category_scores_gemma":[0.0008481338,0.0003781983,0.000850336,0.0006069524,0.0005117364,0.0004513108,0.001125522,0.001366779,0.0007584665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004682676,"about_ca_system_score_gemma":0.0008509471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177276,"about_ca_topic_score_gemma":0.002313471,"domain_scores_codex":[0.9969888,0.0005889364,0.0005322694,0.0005300954,0.000986093,0.0003738545],"domain_scores_gemma":[0.9984277,0.000223468,0.0004764253,0.0004174534,0.0002580863,0.0001968325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003989075,0.0005746933,0.002879865,0.00009442302,0.00002718257,0.00006931126,0.00005805124,0.0003344925,0.993651,0.0000760348,0.0001472464,0.001688803],"study_design_scores_gemma":[0.00008866553,0.013229,0.02642231,0.0000447068,0.0001423626,0.001036385,0.000144579,0.001426121,0.9542118,0.00007992599,0.003127593,0.00004659379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815904,0.000373431,0.01211694,0.0001265056,0.00004961948,0.00171252,0.00234181,0.0001298694,0.001558889],"genre_scores_gemma":[0.9295024,0.000902223,0.05397851,0.0003253245,0.00003872031,0.003771835,0.009119475,0.0001077288,0.002253749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001463101,"threshold_uncertainty_score":0.007737696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892674386165689,"score_gpt":0.2607762020457604,"score_spread":0.2418494581841035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}