{"id":"W4403920830","doi":"10.1016/j.bbi.2024.10.039","title":"Deep brain stimulation halts Parkinson’s disease-related immune dysregulation in the brain and peripheral blood","year":2024,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Avid Radiopharmaceuticals; Allergan; Genentech; H. Lundbeck A/S; Servier; Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg; Deutsche Forschungsgemeinschaft; Sun Pharma; Voyager Therapeutics; Stiftung VERUM; Neurocrine Biosciences; Alexander von Humboldt-Stiftung; Biogen; Celgene; H2020 European Institute of Innovation and Technology; Jazz Pharmaceuticals; Verily Life Sciences; Teva Pharmaceutical Industries; Sanofi; Pfizer; Bristol-Myers Squibb; Eli Lilly and Company","keywords":"Deep brain stimulation; Medicine; Neuroscience; Stimulation; Immune system; Peripheral; Brain stimulation; Parkinson's disease; Disease; Immune dysregulation; Psychology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003444853,0.0001849335,0.0002037145,0.00008902162,0.000188608,0.00009091543,0.00006196926,0.0001043514,0.0001088389],"category_scores_gemma":[0.0001508403,0.0001265335,0.00007191442,0.0002192412,0.0001242665,0.0001421509,0.0000461621,0.0003246717,0.000003091941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002206157,"about_ca_system_score_gemma":0.00002471164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001909221,"about_ca_topic_score_gemma":0.00004761348,"domain_scores_codex":[0.9987867,0.0002946721,0.0002634978,0.0002803659,0.0001698081,0.0002049845],"domain_scores_gemma":[0.9992743,0.0003347784,0.00003478799,0.000246921,0.00001745164,0.00009177139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006497846,0.00252301,0.8328992,0.0001933334,0.0001231626,0.00100958,0.005425767,0.00004629058,0.0109042,0.001153743,0.0005893534,0.1444826],"study_design_scores_gemma":[0.00229767,0.0004309432,0.9914875,0.00006621304,0.0002205102,0.00005140133,0.0001982449,0.003244166,0.00001553666,0.001410508,0.0004527369,0.0001245711],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853927,0.004439275,0.00002489692,0.009091379,0.0000682478,0.0007695372,0.000012701,0.0000669311,0.0001343376],"genre_scores_gemma":[0.9980583,0.00009873593,0.00003044089,0.001156457,0.00001835012,0.00007833797,0.0002008371,0.0000190837,0.0003394923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1585883,"threshold_uncertainty_score":0.5159888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710316041920131,"score_gpt":0.2816524353023667,"score_spread":0.2645492748831654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}