{"id":"W4403920830","doi":"10.1016/j.bbi.2024.10.039","title":"Deep brain stimulation halts Parkinson’s disease-related immune dysregulation in the brain and peripheral blood","year":2024,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Avid Radiopharmaceuticals; Allergan; Genentech; H. Lundbeck A/S; Servier; Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg; Deutsche Forschungsgemeinschaft; Sun Pharma; Voyager Therapeutics; Stiftung VERUM; Neurocrine Biosciences; Alexander von Humboldt-Stiftung; Biogen; Celgene; H2020 European Institute of Innovation and Technology; Jazz Pharmaceuticals; Verily Life Sciences; Teva Pharmaceutical Industries; Sanofi; Pfizer; Bristol-Myers Squibb; Eli Lilly and Company","keywords":"Deep brain stimulation; Medicine; Neuroscience; Stimulation; Immune system; Peripheral; Brain stimulation; Parkinson's disease; Disease; Immune dysregulation; Psychology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001124209,0.0003272965,0.0002583079,0.0001803213,0.00007646387,0.0002226277,0.00009594629,0.000276809,0.001453215],"category_scores_gemma":[0.0001517219,0.00006849592,0.0001463722,0.00007906638,0.0003010698,0.0001548035,0.0001137547,0.0005846488,0.0002367158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009982117,"about_ca_system_score_gemma":0.0001635554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001493135,"about_ca_topic_score_gemma":0.0004288993,"domain_scores_codex":[0.9999379,0.00001487474,0.000004922771,0.0000103868,0.00001490839,0.00001708127],"domain_scores_gemma":[0.999959,0.00001018141,0.00001043074,0.000004741124,0.000003751589,0.00001188742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003032108,0.0002685231,0.0004540407,0.0001150769,0.0000323777,0.0001290547,0.00003152131,0.000208843,0.9595311,0.0001890125,0.0003476698,0.03566068],"study_design_scores_gemma":[0.001357138,0.02134947,0.04385189,0.00007706484,0.0001729177,0.00156906,0.0002411902,0.003219986,0.9158051,0.002312817,0.01001263,0.00003078074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903757,0.002925982,0.002586614,0.0003015672,0.0001396013,0.00003392861,0.000170773,0.0002114214,0.003254442],"genre_scores_gemma":[0.9957112,0.001082042,0.00106653,0.0001172719,0.00002562561,0.0000412163,0.0001540356,0.00001169158,0.001790292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453215,"threshold_uncertainty_score":0.004861534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710316041920131,"score_gpt":0.2816524353023667,"score_spread":0.2645492748831654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}