{"id":"W4403925874","doi":"10.1016/j.stemcr.2024.10.003","title":"Neural crest precursors from the skin are the primary source of directly reprogrammed neurons","year":2024,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Disability Prevention and Rehabilitation; Hospital for Sick Children; Centre for Social Innovation","funders":"Canadian Institutes of Health Research; Cole Foundation; Canada First Research Excellence Fund; Krembil Foundation","keywords":"Biology; Neural crest; Primary (astronomy); Neuroscience; Cell biology; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001674179,0.0002202862,0.0002688784,0.0001854795,0.0001234738,0.0003788258,0.00014917,0.0001812132,0.0009693261],"category_scores_gemma":[0.0002808558,0.0001505209,0.0001306622,0.0001071411,0.0001707085,0.0001572805,0.0002251216,0.0004682716,0.0005104265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006370934,"about_ca_system_score_gemma":0.0001207799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001443576,"about_ca_topic_score_gemma":0.0004558466,"domain_scores_codex":[0.9997413,0.00003664572,0.00002629543,0.00007041762,0.00009637586,0.00002886171],"domain_scores_gemma":[0.9997537,0.00007235628,0.00004232362,0.0000653204,0.00003134866,0.0000350245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000111623,0.00000396175,0.0005404563,0.00001998049,0.000002808428,0.00007983658,0.00002033959,0.00003950192,0.9967276,0.00007511505,0.000009931166,0.002469273],"study_design_scores_gemma":[0.000003958251,0.000118035,0.01219471,0.00001140803,0.00001630837,0.001493569,0.00005963022,0.0004656857,0.9830032,0.00009014978,0.002539923,0.000003473021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794412,0.001108436,0.01379521,0.00003927424,0.00003138618,0.00004985378,0.0002040659,0.0001136494,0.005216982],"genre_scores_gemma":[0.9903809,0.0007211212,0.00627271,0.00003178794,0.000006601257,0.00002264617,0.0002037784,0.0000307751,0.002329645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009693261,"threshold_uncertainty_score":0.003242671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221150332534814,"score_gpt":0.2415607982433163,"score_spread":0.2293492949179682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}