{"id":"W4403933665","doi":"10.1139/cjpp-2024-0232","title":"Pharmacological interactions of jadomycin B with topoisomerase poisons in MDA-MB-231 human breast cancer cells","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Research Institute; Beatrice Hunter Cancer Research Institute","keywords":"Cytotoxicity; Doxorubicin; Mitoxantrone; Pharmacology; Topoisomerase; In vivo; Chemistry; Cancer cell; Cancer; In vitro; Biology; Medicine; Biochemistry; Chemotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002154006,0.0003508916,0.0004709851,0.0003476937,0.0002360138,0.0003317467,0.0002114527,0.0002700306,0.0007839365],"category_scores_gemma":[0.0001328655,0.0002050855,0.0003276283,0.0004103579,0.0001508125,0.0001481215,0.0001739487,0.00059803,0.0002570474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000336546,"about_ca_system_score_gemma":0.0002884178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003079574,"about_ca_topic_score_gemma":0.004312412,"domain_scores_codex":[0.999781,0.00005838157,0.00002624496,0.00002872745,0.00005086007,0.00005485268],"domain_scores_gemma":[0.9999007,0.00002363115,0.00001485004,0.00001016547,0.00001595176,0.00003457987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004863184,0.0001729963,0.0002504706,0.0001054448,0.00002732635,0.00005957386,0.00002874999,0.0001114673,0.9965906,0.0000424398,0.0001465037,0.001978224],"study_design_scores_gemma":[0.0001014815,0.002617593,0.008722477,0.00001520165,0.00005462559,0.0002575309,0.00007438261,0.0009807369,0.9840705,0.00002192159,0.003074096,0.000009331498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890665,0.006768062,0.000829872,0.0002405306,0.00009243515,0.00007298261,0.0008202721,0.0000765908,0.002032767],"genre_scores_gemma":[0.9937333,0.002583941,0.001655691,0.00006628211,0.00001868183,0.00006494911,0.0006687187,0.000007264786,0.001201031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003079574,"threshold_uncertainty_score":0.006123304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243753085169925,"score_gpt":0.3060986039037284,"score_spread":0.2936610730520292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}