{"id":"W4403935446","doi":"10.1016/j.isci.2024.111286","title":"Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Dalhousie University; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Cystic Fibrosis Foundation","keywords":"Quorum sensing; Cystic fibrosis; Innate immune system; Immune system; Microbiology; Taste receptor; Receptor; Chemistry; Biology; Cell biology; Immunology; Bacteria; Biochemistry; Biofilm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007248982,0.0002016551,0.000270332,0.0004465213,0.000147606,0.0003426949,0.0002607536,0.0001095608,0.00002502422],"category_scores_gemma":[0.0004565388,0.0001731703,0.0001058834,0.001408858,0.0002117581,0.0001588327,0.0001711217,0.0002541511,0.00008925274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001316748,"about_ca_system_score_gemma":0.0000355322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003074697,"about_ca_topic_score_gemma":0.00005217456,"domain_scores_codex":[0.9981396,0.00007547437,0.0004126163,0.0005953463,0.000291727,0.0004852388],"domain_scores_gemma":[0.9992044,0.0002935585,0.0000533029,0.0002805364,0.00006988539,0.00009832729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009910845,0.00001493029,0.0002105739,0.00003088307,0.000004947577,0.00002181168,0.0006142008,0.00007524149,0.9876975,0.00001771239,0.001801563,0.009411485],"study_design_scores_gemma":[0.00006912548,0.00008710332,0.0006231823,0.0007818151,0.00002178797,0.00001526731,0.00009514097,0.02582487,0.9665639,0.0002716766,0.005348497,0.0002976495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848548,0.001578236,0.001813988,0.01066055,0.000634057,0.0001126027,0.00001963469,0.0002632987,0.00006281064],"genre_scores_gemma":[0.9721928,0.00002055047,0.02681049,0.0006826417,0.0001044038,0.000003488344,0.00000790699,0.00002565523,0.0001520586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02574963,"threshold_uncertainty_score":0.7061681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128897384510765,"score_gpt":0.2659201226053636,"score_spread":0.254631148760256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}