{"id":"W4403936372","doi":"10.1016/j.ijrobp.2024.10.030","title":"Adding Metastasis-Directed Therapy to Standard-of-Care Systemic Therapy for Oligometastatic Breast Cancer (EXTEND): A Multicenter, Randomized Phase 2 Trial","year":2024,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Society of Intestinal Research","funders":"National Cancer Institute; University of Texas MD Anderson Cancer Center; National Institutes of Health; Cancer Prevention and Research Institute of Texas","keywords":"Medicine; Oncology; Breast cancer; Systemic therapy; Internal medicine; Randomized controlled trial; Metastasis; Cancer; Standard of care","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001504413,0.00184113,0.002485906,0.0003751772,0.0003963686,0.0008675482,0.0008229892,0.001289543,0.005342045],"category_scores_gemma":[0.001222918,0.0004704998,0.001745235,0.00038348,0.001051193,0.001103834,0.0005673438,0.002844058,0.0007446563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007146196,"about_ca_system_score_gemma":0.0008123438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008513993,"about_ca_topic_score_gemma":0.002148907,"domain_scores_codex":[0.9995455,0.0002228553,0.00001823125,0.00009901026,0.00003448299,0.0000798839],"domain_scores_gemma":[0.9993432,0.0002006691,0.0001299245,0.00006357568,0.0000323711,0.0002301739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9727408,0.006456655,0.0008567088,0.000314475,0.0007900911,0.00002294231,0.0000548717,0.0005937013,0.001818394,0.0001055296,0.0007222141,0.01552373],"study_design_scores_gemma":[0.8938282,0.1008693,0.002759132,0.00003433987,0.0006579569,0.00003700519,0.00003531235,0.0004473042,0.000506408,0.0001927605,0.000617464,0.00001486767],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930798,0.002435643,0.0004139557,0.000476301,0.0002850997,0.001289359,0.0005519757,0.00007683173,0.001391034],"genre_scores_gemma":[0.9875228,0.002316822,0.001516277,0.0009742075,0.0004261565,0.002711417,0.001168473,0.00003087298,0.003332978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005342045,"threshold_uncertainty_score":0.0178709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02140360387909822,"score_gpt":0.3789411040287703,"score_spread":0.3575375001496721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}