{"id":"W4403938718","doi":"10.1371/journal.pmed.1004469","title":"Safety and tolerability of tegoprubart in patients with amyotrophic lateral sclerosis: A Phase 2A clinical trial","year":2024,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Tolerability; Medicine; Amyotrophic lateral sclerosis; Internal medicine; Adverse effect; Neuroinflammation; Clinical endpoint; Clinical trial; Immunology; Oncology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001438513,0.001302998,0.001783679,0.000288787,0.0003418884,0.0009053748,0.0006314742,0.001435344,0.002498049],"category_scores_gemma":[0.001050462,0.0003887987,0.001077892,0.0002401883,0.0007617638,0.0008380062,0.0002815701,0.001824332,0.0006244953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000560528,"about_ca_system_score_gemma":0.0009151929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002816893,"about_ca_topic_score_gemma":0.0006306809,"domain_scores_codex":[0.9995847,0.0002154107,0.0000278904,0.00006710675,0.00003720109,0.00006773009],"domain_scores_gemma":[0.9993514,0.0001155393,0.000191147,0.00005193681,0.00005299892,0.0002369425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8640706,0.02661852,0.006529413,0.0008822306,0.001209311,0.0004382599,0.0002892277,0.00132297,0.02449608,0.0001550076,0.001976854,0.07201156],"study_design_scores_gemma":[0.6068754,0.3726627,0.01398279,0.00006410675,0.0004491404,0.0004127515,0.00008150464,0.001250811,0.002307788,0.000173609,0.001700425,0.00003899136],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951006,0.002284939,0.0003065058,0.000282567,0.00005897062,0.0009302582,0.0003967563,0.0000602638,0.0005792742],"genre_scores_gemma":[0.9943961,0.001391831,0.0006435529,0.0005681645,0.0001349277,0.001363701,0.000644478,0.00001337097,0.0008438641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002498049,"threshold_uncertainty_score":0.008356869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0858743881898898,"score_gpt":0.3739703063749486,"score_spread":0.2880959181850588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}