{"id":"W4403938718","doi":"10.1371/journal.pmed.1004469","title":"Safety and tolerability of tegoprubart in patients with amyotrophic lateral sclerosis: A Phase 2A clinical trial","year":2024,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Tolerability; Medicine; Amyotrophic lateral sclerosis; Internal medicine; Adverse effect; Neuroinflammation; Clinical endpoint; Clinical trial; Immunology; Oncology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00120781,0.0002556563,0.001141353,0.0002633297,0.00003935877,0.00001541522,0.0001271562,0.0001795417,0.0005526724],"category_scores_gemma":[0.0007760241,0.0001508639,0.00008640362,0.0005751976,0.0007792533,0.0001448797,0.00009213106,0.0007615164,0.00001408517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000131871,"about_ca_system_score_gemma":0.0001874957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001182041,"about_ca_topic_score_gemma":0.00001488111,"domain_scores_codex":[0.9964082,0.0002581016,0.001289474,0.0006325173,0.0009908782,0.0004207954],"domain_scores_gemma":[0.9984694,0.0003696519,0.0001074226,0.0004700378,0.0002061274,0.0003774235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2721573,0.00641243,0.661774,0.001385569,0.0005930818,0.0001709593,0.001182098,0.000002517662,0.003180034,0.0001339189,0.0006628692,0.05234518],"study_design_scores_gemma":[0.1534216,0.01647809,0.8250537,0.003187567,0.0002216464,0.000004438321,0.00002228439,0.0009776216,0.00004356298,0.00007226582,0.0003642291,0.000152987],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929526,0.0005525765,0.00001756525,0.004117256,0.0002293804,0.001761561,0.00002213302,0.00007006549,0.0002767951],"genre_scores_gemma":[0.9984396,0.000409025,0.0001378448,0.0002425923,0.0004990359,0.00004308103,0.00005542838,0.00003988157,0.0001334845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1632796,"threshold_uncertainty_score":0.615205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0858743881898898,"score_gpt":0.3739703063749486,"score_spread":0.2880959181850588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}