{"id":"W4403943850","doi":"10.1513/annalsats.202405-451rl","title":"Reduction in 3-Year Risk of Death or Lung Transplant for Individuals with Advanced Cystic Fibrosis Lung Disease Treated with Elexacaftor/Tezacaftor/Ivacaftor","year":2024,"lang":"en","type":"letter","venue":"Annals of the American Thoracic Society","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Toronto; Toronto Public Health; St. Michael's Hospital; St. Paul's Hospital; Cystic Fibrosis Canada; Public Health Ontario; University of British Columbia","funders":"","keywords":"Medicine; Ivacaftor; Lung transplantation; Lung disease; Disease; Internal medicine; Lung; Intensive care medicine; Transplantation; Cystic fibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005485812,0.0001932736,0.0005221646,0.0002402809,0.0005858431,0.0005343732,0.0003743728,0.003654547,0.003642005],"category_scores_gemma":[0.004415783,0.00009521522,0.0005369413,0.0002822697,0.0002411295,0.0002724571,0.0001649857,0.002804683,0.001190632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001100875,"about_ca_system_score_gemma":0.001200155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004532766,"about_ca_topic_score_gemma":0.01158601,"domain_scores_codex":[0.9995819,0.0001206482,0.00004439218,0.00004189705,0.0001384788,0.00007267251],"domain_scores_gemma":[0.9987092,0.0005777089,0.0001495628,0.00003482413,0.0002141929,0.0003145412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.004211324,0.000679765,0.07985663,0.0002675408,0.0003364622,0.005408572,0.0001479913,0.0007371735,0.001964773,0.003309561,0.748956,0.1541242],"study_design_scores_gemma":[0.00628548,0.004287848,0.3465188,0.0008616752,0.001318601,0.01564859,0.0006436761,0.005852628,0.00227709,0.0149371,0.6012363,0.0001320618],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.05896728,0.009401578,0.0003567099,0.875284,0.01587214,0.00003944927,0.001178298,0.0001230903,0.03877745],"genre_scores_gemma":[0.4151843,0.007947469,0.001267636,0.4852978,0.06080846,0.0001071507,0.001183794,0.00004827718,0.02815507],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004532766,"threshold_uncertainty_score":0.01218367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03409668139078299,"score_gpt":0.3723476524883323,"score_spread":0.3382509710975494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}