{"id":"W4403948499","doi":"10.1038/s42255-024-01153-1","title":"Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise","year":2024,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Foundation Center for Basic Metabolic Research; Novo Nordisk Fonden; Danmarks Frie Forskningsfond","keywords":"Medicine; Skeletal muscle; Internal medicine; Metabolic syndrome; Insulin; Endocrinology; Diabetes mellitus","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387462,0.0007815042,0.0002843561,0.000582627,0.0005738707,0.0002845877,0.0002680314,0.0003715308,0.002321079],"category_scores_gemma":[0.0003367428,0.0001838392,0.0001959703,0.0003627794,0.0005219556,0.0001125866,0.0003515631,0.0002255533,0.0002338471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002599982,"about_ca_system_score_gemma":0.0001599203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01045665,"about_ca_topic_score_gemma":0.01342947,"domain_scores_codex":[0.9998852,0.00001324958,0.00001083645,0.00003862348,0.00002773777,0.00002430726],"domain_scores_gemma":[0.9998974,0.0000162989,0.00003808085,0.000009257591,0.00001402762,0.00002501183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001857008,0.0002943592,0.294559,0.000168438,0.0002732785,0.02733597,0.001363585,0.0002216518,0.6438819,0.0003235217,0.001000446,0.02872099],"study_design_scores_gemma":[0.00006999102,0.001176708,0.9335622,0.00004484143,0.0002065416,0.03876255,0.0007649183,0.000600818,0.02130624,0.0002286002,0.003239731,0.00003689917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986082,0.0002040236,0.0003424328,0.00006412912,0.000011971,0.00001010212,0.0001618133,0.00001379017,0.0005835657],"genre_scores_gemma":[0.9979833,0.0002117402,0.0003644088,0.00005599,0.000008067209,0.00001320074,0.000255254,0.00001568324,0.001092214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01045665,"threshold_uncertainty_score":0.02079159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004822148744626799,"score_gpt":0.2312044807795388,"score_spread":0.226382332034912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}