{"id":"W4403948499","doi":"10.1038/s42255-024-01153-1","title":"Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise","year":2024,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Foundation Center for Basic Metabolic Research; Novo Nordisk Fonden; Danmarks Frie Forskningsfond","keywords":"Medicine; Skeletal muscle; Internal medicine; Metabolic syndrome; Insulin; Endocrinology; Diabetes mellitus","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005187382,0.0006969419,0.0008022347,0.0002915461,0.0002647497,0.0002644479,0.00064235,0.001115635,0.0006650392],"category_scores_gemma":[0.0001994427,0.0006177993,0.0005716313,0.0004734397,0.0001672858,0.00005652553,0.0003238567,0.001116581,0.0001350134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003385219,"about_ca_system_score_gemma":0.000424018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002243032,"about_ca_topic_score_gemma":0.00006041837,"domain_scores_codex":[0.9960135,0.0002776537,0.0006392578,0.001421811,0.0007157965,0.0009320186],"domain_scores_gemma":[0.9980828,0.0000493498,0.0001498828,0.001096771,0.0002245132,0.0003966391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001850855,0.0001720523,0.00007017605,0.0002530474,0.001216444,0.0003726638,0.001569079,0.00002033415,0.8587413,0.001534439,0.01689888,0.1173007],"study_design_scores_gemma":[0.0009523283,0.00002280554,0.01931002,0.00007735551,0.0004181775,0.00001454531,0.0000880463,0.00002126128,0.3124355,0.0002940633,0.6657611,0.0006047635],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5143616,0.4816407,0.00003217206,0.0001085007,0.002010785,0.000225291,0.001218765,0.00007417076,0.0003280102],"genre_scores_gemma":[0.8957679,0.09469924,0.0009434656,0.001576987,0.003445529,0.0001207691,0.000343422,0.0001686338,0.00293403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6488622,"threshold_uncertainty_score":0.9996274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004822148744626799,"score_gpt":0.2312044807795388,"score_spread":0.226382332034912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}