{"id":"W4403954504","doi":"10.1093/ofid/ofae638","title":"4CMenB Breadth of Immune Response, Immunogenicity, and Safety: Results From a Phase 3 Randomized, Controlled, Observer Blind Study in Adolescents and Young Adults","year":2024,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"Medicine; Immunogenicity; Randomized controlled trial; Immune system; Antibody response; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007128954,0.001390203,0.002986202,0.0004221769,0.0006274742,0.0008077676,0.001052806,0.002073427,0.004167804],"category_scores_gemma":[0.00365233,0.0008246129,0.001577194,0.0004760453,0.001653349,0.00110486,0.0005100104,0.002291844,0.0005310341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000702734,"about_ca_system_score_gemma":0.002024916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009027937,"about_ca_topic_score_gemma":0.001812495,"domain_scores_codex":[0.9972377,0.001720021,0.0001961499,0.0003424093,0.0002363819,0.0002674015],"domain_scores_gemma":[0.9968228,0.0008968299,0.0009228537,0.0002816266,0.0002914097,0.0007844828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9506748,0.02989073,0.002834162,0.0004121031,0.0007755303,0.00003601932,0.0001386345,0.0001435139,0.003902292,0.00004760034,0.0003577899,0.01078686],"study_design_scores_gemma":[0.7451181,0.2449084,0.008201389,0.00003364203,0.0004244558,0.00002912622,0.00003596018,0.0001885351,0.0006046491,0.00007215156,0.0003713486,0.00001218842],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900423,0.001424781,0.0006964767,0.0001813006,0.0001384581,0.006416152,0.0005452132,0.00005561504,0.0004996583],"genre_scores_gemma":[0.9812554,0.001270338,0.00301226,0.0008257798,0.0003218753,0.01135341,0.0006307204,0.00002861187,0.00130156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007128954,"threshold_uncertainty_score":0.03770196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075181979154212,"score_gpt":0.2833673216005058,"score_spread":0.2726155018089637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}