{"id":"W4403954504","doi":"10.1093/ofid/ofae638","title":"4CMenB Breadth of Immune Response, Immunogenicity, and Safety: Results From a Phase 3 Randomized, Controlled, Observer Blind Study in Adolescents and Young Adults","year":2024,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"Medicine; Immunogenicity; Randomized controlled trial; Immune system; Antibody response; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001127727,0.0003276757,0.001455155,0.0002881486,0.000237643,0.0002334762,0.0002051899,0.0001712722,0.0001629689],"category_scores_gemma":[0.0006801516,0.0002532796,0.000231082,0.0002688591,0.000206454,0.0004084765,0.000503692,0.0002321309,0.00002200441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004891205,"about_ca_system_score_gemma":0.0001141673,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01613646,"about_ca_topic_score_gemma":0.002677358,"domain_scores_codex":[0.996724,0.001203557,0.001147116,0.0005693968,0.00003829336,0.0003176497],"domain_scores_gemma":[0.9984638,0.0007610371,0.0002638133,0.0003645001,0.00009704621,0.00004978915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9070416,0.002731636,0.07206323,0.00004739875,0.001522251,0.00001747089,0.0009511549,0.000002451501,0.01107128,0.00009510788,0.0001449334,0.004311454],"study_design_scores_gemma":[0.7974516,0.00120031,0.1971948,0.0008509537,0.0007507095,0.00005725872,0.001018819,0.00005007672,0.0003901285,0.0003068248,0.0003899598,0.0003385519],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784173,0.01492866,0.000006247642,0.0001337579,0.001073608,0.004010778,0.001158035,0.00006689382,0.0002047451],"genre_scores_gemma":[0.9982116,0.0008647303,0.000002157924,0.00002439452,0.00002418061,0.0003130622,0.0002144866,0.0000294094,0.0003159477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1251316,"threshold_uncertainty_score":0.999992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075181979154212,"score_gpt":0.2833673216005058,"score_spread":0.2726155018089637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}