{"id":"W4403954884","doi":"10.1002/adfm.202413220","title":"Acid‐Responsive Polymer Additives Increase RNA Transfection from Lipid Nanoparticles","year":2024,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Materials science; Transfection; Nanoparticle; Polymer; Nanotechnology; RNA; Chemical engineering; Biochemistry; Composite material; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000121958,0.0004534035,0.0001675364,0.0002041963,0.00008158317,0.000221218,0.0001249562,0.0002631181,0.001606217],"category_scores_gemma":[0.0002037857,0.0001765484,0.0001689794,0.00009561129,0.0001619743,0.0002167913,0.0002240395,0.0003352184,0.0004539888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002982045,"about_ca_system_score_gemma":0.0001643296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003698855,"about_ca_topic_score_gemma":0.0004838433,"domain_scores_codex":[0.999886,0.00002315724,0.000009414666,0.00002882446,0.00003216588,0.00002038129],"domain_scores_gemma":[0.9998686,0.00004440495,0.00004283827,0.000007365929,0.00001765246,0.00001913892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002476767,0.000006971282,0.00002181922,0.00001536596,0.000001506198,0.00001120155,0.000004894111,0.00004536769,0.9993052,0.00002785127,0.00001318327,0.0005217688],"study_design_scores_gemma":[0.000003093812,0.00007340029,0.0002097495,0.000001907021,0.000004294374,0.00001851379,0.000001679023,0.0003040748,0.9987451,0.000007974205,0.0006287986,0.000001416713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853436,0.00173788,0.007571169,0.00009719376,0.00004116275,0.00005136984,0.0001402839,0.0002087855,0.004808597],"genre_scores_gemma":[0.9879068,0.0006902961,0.005976884,0.0001088535,0.00001616729,0.00004769556,0.0001886204,0.00006465937,0.005000043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606217,"threshold_uncertainty_score":0.005373359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008261138102768613,"score_gpt":0.23090859414236,"score_spread":0.2226474560395914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}